[Chemical equation presented] A directing group-free approach for C2-selective carbenoid functionalization of NH-indoles is presented. Using [RuCl2(p-cymene)]2as catalyst and α-aryldiazoesters as carbenoid source, 2-alkylated indoles were obtained in up to 96% isolated yield. Similarly, a regioselective carbenoid functionalization of NH-pyrroles was also achieved.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry