Ruthenium catalyzed directing group-free C2-selective carbenoid functionalization of indoles by α-aryldiazoesters

Wai Wing Chan, Shing Hin Yeung, Zhongyuan Zhou, Albert S.C. Chan, Wing Yiu Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

114 Citations (Scopus)

Abstract

[Chemical equation presented] A directing group-free approach for C2-selective carbenoid functionalization of NH-indoles is presented. Using [RuCl2(p-cymene)]2as catalyst and α-aryldiazoesters as carbenoid source, 2-alkylated indoles were obtained in up to 96% isolated yield. Similarly, a regioselective carbenoid functionalization of NH-pyrroles was also achieved.
Original languageEnglish
Pages (from-to)604-607
Number of pages4
JournalOrganic Letters
Volume12
Issue number3
DOIs
Publication statusPublished - 5 Feb 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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