Roles and relevance of mast cells in infection and vaccination

Yu Fang, Xiang Zou

Research output: Journal article publicationReview articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

� 2016 by the Journal of Biomedical Research. In addition to their well-established role in allergy mast cells have been described as contributing to functional regulation of both innate and adaptive immune responses in host defense. Mast cells are of hematopoietic origin but typically complete their differentiation in tissues where they express immune regulatory functions by releasing diverse mediators and cytokines. Mast cells are abundant at mucosal tissues which are portals of entry for common infectious agents in addition to allergens. Here, we review the current understanding of the participation of mast cells in defense against infection. We also discuss possibilities of exploiting mast cell activation to provide adequate adjuvant activity that is needed in high-quality vaccination against infectious diseases.
Original languageEnglish
Pages (from-to)253-263
Number of pages11
JournalJournal of Biomedical Research
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Adjuvant
  • Host defense
  • Infection
  • Mast cell
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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