Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits

B. Dongés, L.M. Haupt, R.A. Lea, R.C.K. Chan, Ho Keung David Shum, L.R. Griffiths

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

Human memory is a complex neurocognitive process. By combining psychological and molecular genetics expertise, we examined the APOE ?4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults. To assess memory type we used a range of memory tests of both retrospective and prospective memory. Genotypes were determined using RFLP analysis and compared with mean memory scores using univariate ANOVAs. Despite a modest sample size (n=. 197), our study found a significant effect of the APOE ?4 polymorphism in prospective memory. Supporting our hypothesis, a significant difference was demonstrated between genotype groups for means of the Comprehensive Assessment of Prospective Memory total score (p=. 0.036; ?4 alleles. =. 1.99; all other alleles. =. 1.86). In addition, we demonstrate a significant interactive effect between the APOE ?4 and COMT polymorphisms in semantic memory. This is the first study to investigate both APOE and COMT genotypes in relation to memory in non-pathological adults and provides important information regarding the effect of genetic determinants on human memory. © 2012 Elsevier B.V.
Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalGene
Volume506
Issue number1
DOIs
Publication statusPublished - 10 Sep 2012
Externally publishedYes

Keywords

  • APOE
  • COMT
  • Genetics of memory
  • Prospective memory
  • Retrospective memory

ASJC Scopus subject areas

  • Genetics

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