Abstract
BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. KGaA,.
Original language | English |
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Pages (from-to) | 7314-7323 |
Number of pages | 10 |
Journal | Chemistry - A European Journal |
Volume | 14 |
Issue number | 24 |
DOIs | |
Publication status | Published - 18 Aug 2008 |
Externally published | Yes |
Keywords
- Metathesis
- Organic chemistry
- Ruthenium
- Synthesis
- Taxol
ASJC Scopus subject areas
- Chemistry(all)