Ring-closing metathesis in the synthesis of BC ring-systems of taxol

Cong Ma; Stéphanie Schiltz; Xavier F. Le Goff; Joëlle Prunet

doi:10.1002/chem.200800774

Ring-closing metathesis in the synthesis of BC ring-systems of taxol

Cong Ma, Stéphanie Schiltz, Xavier F. Le Goff, Joëlle Prunet

Research output: Journal article publication › Journal article › Academic research › peer-review

31 Citations (Scopus)

Abstract

BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. KGaA,.

Original language	English
Pages (from-to)	7314-7323
Number of pages	10
Journal	Chemistry - A European Journal
Volume	14
Issue number	24
DOIs	https://doi.org/10.1002/chem.200800774
Publication status	Published - 18 Aug 2008
Externally published	Yes

Keywords

Metathesis
Organic chemistry
Ruthenium
Synthesis
Taxol

ASJC Scopus subject areas

Chemistry(all)

More information

10.1002/chem.200800774

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abstract = "BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. KGaA,.",

keywords = "Metathesis, Organic chemistry, Ruthenium, Synthesis, Taxol",

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AU - Ma, Cong

AU - Schiltz, Stéphanie

AU - Le Goff, Xavier F.

AU - Prunet, Joëlle

PY - 2008/8/18

Y1 - 2008/8/18

N2 - BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. KGaA,.

AB - BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. KGaA,.

KW - Metathesis

KW - Organic chemistry

KW - Ruthenium

KW - Synthesis

KW - Taxol

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U2 - 10.1002/chem.200800774

DO - 10.1002/chem.200800774

M3 - Journal article

C2 - 18600828

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

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ER -

Ring-closing metathesis in the synthesis of BC ring-systems of taxol

Abstract

Keywords

ASJC Scopus subject areas

More information

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