Ring-closing metathesis in the synthesis of BC ring-systems of taxol

Cong Ma, Stéphanie Schiltz, Xavier F. Le Goff, Joëlle Prunet

Research output: Journal article publicationJournal articleAcademic researchpeer-review

29 Citations (Scopus)

Abstract

BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail. KGaA,.
Original languageEnglish
Pages (from-to)7314-7323
Number of pages10
JournalChemistry - A European Journal
Volume14
Issue number24
DOIs
Publication statusPublished - 18 Aug 2008
Externally publishedYes

Keywords

  • Metathesis
  • Organic chemistry
  • Ruthenium
  • Synthesis
  • Taxol

ASJC Scopus subject areas

  • Chemistry(all)

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