Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines

Ka Ho Ng; Zhongyuan Zhou; Wing Yiu Yu

doi:10.1021/ol203046n

Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines

Ka Ho Ng, Zhongyuan Zhou, Wing Yiu Yu

Research output: Journal article publication › Journal article › Academic research › peer-review

197 Citations (Scopus)

Abstract

A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

Original language	English
Pages (from-to)	272-275
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	1
DOIs	https://doi.org/10.1021/ol203046n
Publication status	Published - 6 Jan 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol203046n

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title = "Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines",

abstract = "A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.",

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AU - Zhou, Zhongyuan

AU - Yu, Wing Yiu

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N2 - A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

AB - A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

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DO - 10.1021/ol203046n

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JO - Organic Letters

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Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines

Abstract

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