Rhodium-catalyzed asymmetric addition of arylboronic acids to β-phthaliminoacrylate esters toward the synthesis of β-amino acids

Takahiro Nishimura, Jun Wang, Makoto Nagaosa, Kazuhiro Okamoto, Ryo Shintani, Fuk Yee Kwong, Wing Yiu Yu, Albert S.C. Chan, Tamio Hayashi

Research output: Journal article publicationJournal articleAcademic researchpeer-review

64 Citations (Scopus)

Abstract

(Chemical Equation Presented) Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to β-phthaliminoacrylate esters took place efficiently to give high yields of β-aryl-β-amino acid esters with 96-99% enantioselectivity, which was realized by use of a hydroxorhodium/chiral diene complex.
Original languageEnglish
Pages (from-to)464-465
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number2
DOIs
Publication statusPublished - 20 Jan 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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