Rh-catalyzed intermolecular carbenoid functionalization of aromatic C-H bonds by α-diazomalonates

Wai Wing Chan, Siu Fung Lo, Zhongyuan Zhou, Wing Yiu Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

357 Citations (Scopus)

Abstract

A Rh-catalyzed intermolecular coupling of diazomalonates with arene C-H bonds is reported. The reaction is initiated by electrophilic C-H activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross-couple with diazomalonates with excellent regioselectivities and functional group tolerance, and thus, this reaction offers a new route to α-aryl carbonyl compounds for specific applications.
Original languageEnglish
Pages (from-to)13565-13568
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number33
DOIs
Publication statusPublished - 22 Aug 2012

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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