Revisiting the adhesion mechanism of mussel-inspired chemistry

Chao Zhang, Li Xiang, Jiawen Zhang, Chang Liu, Zuankai Wang, Hongbo Zeng, Zhi Kang Xu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

50 Citations (Scopus)


Mussel-inspired chemistry has become an ideal platform to engineer a myriad of functional materials, but fully understanding the underlying adhesion mechanism is still missing. Particularly, one of the most pivotal questions is whether catechol still plays a dominant role in molecular-scale adhesion like that in mussel adhesive proteins. Herein, for the first time, we reveal an unexplored adhesion mechanism of mussel-inspired chemistry that is strongly dictated by 5,6-dihydroxyindole (DHI) moieties, amending the conventional viewpoint of catechol-dominated adhesion. We demonstrate that polydopamine (PDA) delivers an unprecedented adhesion of 71.62 mN m-1, which surpasses that of many mussel-inspired derivatives and is even 121-fold higher than that of polycatechol. Such a robust adhesion mainly stems from a high yield of DHI moieties through a delicate synergy of leading oxidation and subsidiary cyclization within self-polymerization, allowing for governing mussel-inspired adhesion by the substituent chemistry and self-polymerization manner. The adhesion mechanisms revealed in this work offer a useful paradigm for the exploitation of functional mussel-inspired materials.

Original languageEnglish
Pages (from-to)1698-1705
Number of pages8
JournalChemical Science
Issue number6
Publication statusPublished - 14 Feb 2022
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


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