Reversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics

Wenbo He, Jiaxiang Bai, Xu Chen, Di Suo, Shenghao Wang, Qianping Guo, Weiling Yin, Dechun Geng, Miao Wang, Guoqing Pan, Xin Zhao, Bin Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)


Dynamic biomaterials excel at recapitulating the reversible interlocking and remoldable structure of the extracellular matrix (ECM), particularly in manipulating cell behaviors and adapting to tissue morphogenesis. While strategies based on dynamic chemistries have been extensively studied for ECM-mimicking dynamic biomaterials, biocompatible molecular means with biogenicity are still rare. Here, we report a nature-derived strategy for fabrication of dynamic biointerface as well as a three-dimensional (3D) hydrogel structure based on reversible receptor–ligand interaction between the glycopeptide antibiotic vancomycin and dipeptide D-Ala-D-Ala. We demonstrate the reversible regulation of multiple cell types with the dynamic biointerface and successfully implement the dynamic hydrogel as a functional antibacterial 3D scaffold to treat tissue repair. In view of the biogenicity and high applicability, this nature-derived reversible molecular strategy will bring opportunities for malleable biomaterial design with great potential in biomedicine.

Original languageEnglish
Article numbere2117221119
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
Publication statusPublished - 22 Feb 2022


  • Biomimicry
  • Cell regulation
  • Dynamic biomaterial design
  • Natural receptor–ligand interaction
  • Tissue repair

ASJC Scopus subject areas

  • General


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