@article{aa6d97a0b4114329901ad208738a38f2,
title = "Retinal ganglion cells encode differently in the myopic mouse retina?",
abstract = "The etiology of myopia remains unclear. This study investigated whether retinal ganglion cells (RGCs) in the myopic retina encode visual information differently from the normal retina and to determine the role of Connexin (Cx) 36 in this process. Generalized linear models (GLMs), which can capture stimulus-dependent changes in real neurons with spike timing precision and reliability, were used to predict RGCs responses to focused and defocused images in the retinas of wild-type (normal) and Lens-Induced Myopia (LIM) mice. As the predominant subunit of gap junctions in the mouse retina and a plausible modulator in myopia development, Cx36 knockout (KO) mice were used as a control for an intact retinal circuit. The kinetics of excitatory postsynaptic currents (EPSCs) of a single αRGC could reflect projection of both focused and defocused images in the retinas of normal and LIM, but not in the Cx36 knockout mice. Poisson GLMs revealed that RGC encoding of visual stimuli in the LIM retina was similar to that of the normal retina. In the LIM retinas, the linear-Gaussian GLM model with offset was a better fit for predicting the spike count under a focused image than the defocused image. Akaike information criterion (AIC) indicated that nonparametric GLM (np-GLM) model predicted focused/defocused images better in both LIM and normal retinas. However, the spike counts in 33% of αRGCs in LIM retinas were better fitted by exponential GLM (exp-GLM) under defocus, compared to only 13% αRGCs in normal retinas. The differences in encoding performance between LIM and normal retinas indicated the possible amendment and plasticity of the retinal circuit in myopic retinas. The absence of a similar response between Cx36 KO mice and normal/LIM mice might suggest that Cx36, which is associated with myopia development, plays a role in encoding focused and defocused images. ",
keywords = "Machine learning, Myopia, Retina, Retinal ganglion cells (RGCs), Vision",
author = "Qin Wang and So, {Chung Him} and Bing Zuo and Seema Banerjee and Chunting Qiu and Ting Zhang and Cheong, {Allen Ming Yan} and Tse, {Yan Yin} and Feng Pan",
note = "Funding Information: As with normal retinas, the rate prediction was better fitted with the nonlinearity GLM model (np-GLM) estimate, with AIC indicating that the np-GLM prediction rate was better in focused/defocused images in LIM retinas (Fig. 5). This was supported by the AIC difference between exp-GLM and np-GLM: 323 (for the ON αRGCs) and 426 (for the OFF αRGCs) under focused images. Two-thirds (10 out of 15, 66.7%) of ON and OFF αRGCs in LIM retinas showed a better fit with np-GLM, while the remaining five ON and OFF αRGCs had a better fit by exp-GLM (33.3%) under −10D and −20D defocused images separately (as shown in Supplemental Fig. 4). This indicated that αRGCs had different coding performances under defocused images in LIM retinas.This study was supported by The Hong Kong Polytechnic University grant: UAG4, UAHA, UALC, UAQC and University Research Facility in Behavioral and Systems Neuroscience. This study was also supported by the Hong Kong Research Grants Council (ECS/RGC; 25103918 (FP); 15106018 (DT), Hong Kong, SAR); InnoHK initiative and the Hong Kong Special Administrative Region Government. “百城百园” 专项启动基金{"} (I2021A010); 深圳市基础研究(面上项目) (Shenzhen Municipal Science and Technology Innovation Commission, JCYJ20210324130809025). Funding Information: This study was supported by The Hong Kong Polytechnic University grant: UAG4 , UAHA , UALC , UAQC and University Research Facility in Behavioral and Systems Neuroscience . This study was also supported by the Hong Kong Research Grants Council ( ECS/RGC; 25103918 (FP) ; 15106018 (DT) , Hong Kong, SAR); InnoHK initiative and the Hong Kong Special Administrative Region Government . {"}百城百园{"} 专项启动基金{"} (I2021A010); 深圳市基础研究(面上项目) ( Shenzhen Municipal Science and Technology Innovation Commission , JCYJ20210324130809025 ). Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = sep,
doi = "10.1016/j.exer.2023.109616",
language = "English",
volume = "234",
journal = "Experimental Eye Research",
issn = "0014-4835",
publisher = "Academic Press Inc.",
}