Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

Shuzhong He, Hongguang Li, Yuk Wang Yip, Chi Tung Yeung, Yuen On Fung, Hoi Kuan Kong, Ho Lun Yeung, Ga Lai Law, Ka Leung Wong, Chi Sing Lee, Michael Hon Wah Lam, Margaret B. Murphy, Paul Kwan Sing Lam, Wing Tak Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.
Original languageEnglish
Pages (from-to)5036-5039
Number of pages4
JournalOrganic Letters
Volume13
Issue number19
DOIs
Publication statusPublished - 7 Oct 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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