Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

Shuzhong He; Hongguang Li; Yuk Wang Yip; Chi Tung Yeung; Yuen On Fung; Hoi Kuan Kong; Ho Lun Yeung; Ga Lai Law; Ka Leung Wong; Chi Sing Lee; Michael Hon Wah Lam; Margaret B. Murphy; Paul Kwan Sing Lam; Wing Tak Wong

doi:10.1021/ol2018246

Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

Shuzhong He, Hongguang Li, Yuk Wang Yip, Chi Tung Yeung, Yuen On Fung, Hoi Kuan Kong, Ho Lun Yeung, Ga Lai Law, Ka Leung Wong, Chi Sing Lee, Michael Hon Wah Lam, Margaret B. Murphy, Paul Kwan Sing Lam, Wing Tak Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

4 Citations (Scopus)

Abstract

A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.

Original language	English
Pages (from-to)	5036-5039
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1021/ol2018246
Publication status	Published - 7 Oct 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol2018246

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@article{87e70598227847df8556543f4221f3bb,

title = "Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin",

abstract = "A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.",

author = "Shuzhong He and Hongguang Li and Yip, {Yuk Wang} and Yeung, {Chi Tung} and Fung, {Yuen On} and Kong, {Hoi Kuan} and Yeung, {Ho Lun} and Law, {Ga Lai} and Wong, {Ka Leung} and Lee, {Chi Sing} and Lam, {Michael Hon Wah} and Murphy, {Margaret B.} and Lam, {Paul Kwan Sing} and Wong, {Wing Tak}",

year = "2011",

month = oct,

day = "7",

doi = "10.1021/ol2018246",

language = "English",

volume = "13",

pages = "5036--5039",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

AU - He, Shuzhong

AU - Li, Hongguang

AU - Yip, Yuk Wang

AU - Yeung, Chi Tung

AU - Fung, Yuen On

AU - Kong, Hoi Kuan

AU - Yeung, Ho Lun

AU - Law, Ga Lai

AU - Wong, Ka Leung

AU - Lee, Chi Sing

AU - Lam, Michael Hon Wah

AU - Murphy, Margaret B.

AU - Lam, Paul Kwan Sing

AU - Wong, Wing Tak

PY - 2011/10/7

Y1 - 2011/10/7

N2 - A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.

AB - A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.

UR - http://www.scopus.com/inward/record.url?scp=84988043620&partnerID=8YFLogxK

U2 - 10.1021/ol2018246

DO - 10.1021/ol2018246

M3 - Journal article

SN - 1523-7060

VL - 13

SP - 5036

EP - 5039

JO - Organic Letters

JF - Organic Letters

IS - 19

ER -

Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

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