Respiratory flow in obstructed airways

X. L. Yang, Yang Liu, H. Y. Luo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

70 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in human community. The COPD always results in inflammation that leads to narrowing and obstruction of the airways. The obstructive airways have significant effect on respiratory flow. In order to understand the flow phenomenon in such obstructive airways, four three-dimensional four-generation lung models based on the 23-generation model of Weibel [1963. Morphometry of the Human Lung. Springer, Academic Press, Berlin, New York] are generated. The fully three-dimensional incompressible laminar Navier-Stokes equations are solved using computational fluid dynamics (CFD) solver on unstructured tetrahedral meshes. Therein, a symmetric four-generation airway model is served as the reference, the other three models are considered to be obstructed at each generation, respectively. The calculation results show that the obstructive airway has significant influence on the air flow in both up- and down-stream airways and it even results in flow separation in the conjunction region. The re-circulation cell blocks the air from entering the downstream branches. This may be the reason why COPD patients should breathe gently, and this also provides some valuable information for medicine powder deposition.
Original languageEnglish
Pages (from-to)2743-2751
Number of pages9
JournalJournal of Biomechanics
Volume39
Issue number15
DOIs
Publication statusPublished - 31 Oct 2006

Keywords

  • CFD
  • COPD
  • Four-generation
  • Respiratory flow

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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