Resistin gene polymorphisms and progression of glycaemia in southern Chinese: A 5-year prospective study

Jian Yu Xu, Pak C. Sham, Aimin Xu, Annette W.K. Tso, Nelson M.S. Wat, King Yip Cheng, Carol H.Y. Fong, Edward D. Janus, Karen S.L. Lam

Research output: Journal article publicationJournal articleAcademic researchpeer-review

36 Citations (Scopus)

Abstract

Objective: Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. Design and patients: We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, -420C→G and +62G→A, previously reported in cross-sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort. Results: We identified 15 polymorphisms, including 2 novel but rare polymorphisms (-319G→A and +63G→C). Compared to subjects with the CC genotype, -420GG subjects had higher 2-h glucose (7.7 ± 1.8 vs. 7.2 ± 2.0 mmol/l, P = 0.011) and insulin (101.6 ± 69.5 vs. 79.8 ± 59.5 mU/l, P = 0.021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25.3 ± 4.0 vs. 24.5 ± 3.6 kg/m 2 in GG, P = 0.02). The presence of the allele -420G (OR 2.15, 95% CI 1.28-3.60, P = 0.004) or +62A (OR1.86, 95% CI 1.08-3.21, P = 0.025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G-A also conferred a higher risk of progression in glycaemia (P = 0.002). Conclusion: Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.
Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalClinical Endocrinology
Volume66
Issue number2
DOIs
Publication statusPublished - 1 Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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