Research progress in characterizing multiple-target mechanisms of novel anti-Alzheimer's dimers

Wei Su, Long Jun Zhu, Da Ping Xu, Wei Cui, Zai Jun Zhang, Sheng Quan Hu, Shing Hung Mak, Yifan Han

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a complex disease caused by environmental and genetic factors. Therefore, onedrug-multiple-target compounds represent the most promising pharmacological approaches to preventing and treating this disease. We have previously designed and synthesized bis(n)-Cognitin, novel anti-Alzheimer' s dimers derived from tacrine. Bis (n)-Cognitin have been proven to act on multiple important AD targets, including acetylcholinesterase, β-secretase, N-methyl-D-aspartic acid receptor and neuronal nitric oxide synthase, concurrently. Moreover, Bis(n)-Cognitin could inhibit β-amyloidinduced neurotoxicity, decrease glutamate-induced excitotoxicity, reduce oxidative stress, improve learning and memory, and protect against neuronal apoptosis in various in vitro and in vivo models, suggesting that bis (n)-Cognitin are potential anti-AD drug candidates.
Original languageEnglish
Pages (from-to)1201-1205
Number of pages5
JournalChinese Pharmacological Bulletin
Volume30
Issue number9
DOIs
Publication statusPublished - 1 Sep 2014

Keywords

  • Acetylcholinesterase
  • Alzheimer's disease
  • Bis(n)-Cognitin
  • Molecular mechanisms
  • Multiple targets
  • Neuroprotection
  • β-amyloid

ASJC Scopus subject areas

  • Pharmacology

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