Research on imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS), Academia Sinica

Hui Chen Tsai, Chun Fang Chang, Bi Chang Chen, Ji Yen Cheng, Chih Wei Chu, Hsieh Cheng Han, Koji Hatanaka, Tung Han Hsieh, Chau Hwang Lee, Jung Hsin Lin, Yi Chung Tung, Pei Kuen Wei, Fu Liang Yang, Din Ping Tsai

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


Development of imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS) of Academia Sinica in Taiwan is progressing rapidly. The research on advanced lattice light sheet microscopy for temporal visualization of cells in three dimensions at sub-cellular resolution shows novel imaging results. Label-free observation on filopodial dynamics provides a convenient assay on cancer cell motility. The newly-developed software enables us to track the movement of two types of particles through different channels and reconstruct the co-localized tracks. Surface plasmon resonance (SPR) for detecting urinary microRNA for diagnosis of acute kidney injury demonstrates excellent sensitivity. A fully automated and integrated portable reader was constructed as a home-based surveillance system for post-operation hepatocellular carcinoma. New microfluidic cell culture devices for fast and accurate characterizations prove various diagnosis capabilities.

Original languageEnglish
Title of host publicationBiophotonics Japan 2015
EditorsTakashige Omatsu, Yasuyuki Ozeki, Seigo Ohno, Yoshio Hayasaki, Yusuke Ogura
ISBN (Electronic)9781510600270
Publication statusPublished - Oct 2015
Externally publishedYes
EventBiophotonics Japan 2015 - Tokyo, Japan
Duration: 27 Oct 201528 Oct 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceBiophotonics Japan 2015


  • Cell imaging
  • lattice light sheet microscopy
  • microfluidic cell culture devices
  • sensing technology
  • surface plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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