Abstract
Purpose : Bruch’s membrane opening minimum rim width (BMO-MRW) has been popularly used to evaluate and monitor glaucoma. Neuroretinal rim (NRR) thickness also shared good diagnostic ability. This study investigated repeatability and agreement among multiple NRR thickness acquisitions. We also evaluated its ISNT/IST patterns and effect from axial length (AL).
Methods : 100 eyes (100 healthy subjects) had NRR thickness measured 5 times consecutively. Signal strength was at least 7 with no obvious artifacts. NRR thickness and retinal nerve fiber layer (RNFL) thickness were obtained. An average from all 5 acquisitions was considered as reference standard. The first, average from the first 2, first 3, and first 4 acquisitions were compared with the reference standard. AL was measured using partial coherence interferometry. Correlations between AL and NRR thickness, and RNFL thickness were studied. Number of eyes following the ISNT and IST patterns were counted.
Results : 87 eyes fulfilled the inclusion criteria. Table 1 shows repeatability and coefficient of variation among 5 acquisitions. They demonstrated comparable results. Table 2 shows agreement between different averaging methods with the reference standard. Agreement improved with averaging from more acquisitions. There were significant correlations between superior/inferior RNFL thickness and AL (r=0.28, p=0.008 and r=0.40, p
Conclusions : One NRR acquisition could provide valid information for clinical use. NRR thickness is less affected by AL for evaluating ganglion cell axons.
Methods : 100 eyes (100 healthy subjects) had NRR thickness measured 5 times consecutively. Signal strength was at least 7 with no obvious artifacts. NRR thickness and retinal nerve fiber layer (RNFL) thickness were obtained. An average from all 5 acquisitions was considered as reference standard. The first, average from the first 2, first 3, and first 4 acquisitions were compared with the reference standard. AL was measured using partial coherence interferometry. Correlations between AL and NRR thickness, and RNFL thickness were studied. Number of eyes following the ISNT and IST patterns were counted.
Results : 87 eyes fulfilled the inclusion criteria. Table 1 shows repeatability and coefficient of variation among 5 acquisitions. They demonstrated comparable results. Table 2 shows agreement between different averaging methods with the reference standard. Agreement improved with averaging from more acquisitions. There were significant correlations between superior/inferior RNFL thickness and AL (r=0.28, p=0.008 and r=0.40, p
Conclusions : One NRR acquisition could provide valid information for clinical use. NRR thickness is less affected by AL for evaluating ganglion cell axons.
| Original language | English |
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| Title of host publication | Investigative Ophthalmology & Visual Science |
| Pages | 3314 |
| Volume | 63 |
| ISBN (Electronic) | 1552-5783 |
| Publication status | Published - Jun 2022 |
| Event | Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022 - Denver, United States Duration: 1 May 2022 → 4 May 2022 |
Conference
| Conference | Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022 |
|---|---|
| Abbreviated title | ARVO 2022 |
| Country/Territory | United States |
| City | Denver |
| Period | 1/05/22 → 4/05/22 |