Relationship between serum uric acid level and all-cause and cardiovascular mortality in population with obesity

Jie Li, Jia Yi Huang, Lin Liu, Kenneth Lo, Shuo Sun, Chao Lei Chen, Bin Zhang, Ying Qing Feng, Yu Qing Huang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Background We aimed to investigate the association between serum uric acid (SUA) and all-cause or cardiovascular mortality among participants with obesity. Method All participants were included from the 1999 to 2014 National Health and Nutrition Examination Survey with follow-up mortality assessment through 31 December 2015. Cox proportional hazards models were built to estimate adjusted HRs and 95% CIs for mortality according to baseline uric acid in quartiles. Obesity was defined as body mass index ≥30 (kg/m 2). Generalised additive model (GAM) and two-piecewise linear regression models were performed to explore any non-linearity in associations. Results There were 12 637 adults with obesity eligible for analysis. There were 999 (7.91%) all-cause and 147 (1.16%) cardiovascular mortality occurred during the mean follow-up of 98.11 months. Comparing with the lowest quartile of SUA, the highest SUA group did not have significant association with all-cause (HR 1.08, 95% CI 0.76 to 1.52) and cardiovascular mortality (HR 1.63, 95% CI 0.58 to 4.53) after adjusting for various confounding factors. GAM and two-piecewise linear regression model demonstrated a non-linearly relationship between SUA and all-cause mortality, and the corresponding cut-off point was 6.5 mg/dL. However, there is no significant relationship between uric acid and cardiovascular death on both sides of the cut-off value of 6.1 mg/dL. Conclusions SUA showed a J-shaped relationship with all-cause mortality, but no significant with cardiovascular mortality in adults with obesity.

Original languageEnglish
Pages (from-to)660-665
Number of pages6
JournalPostgraduate Medical Journal
Volume96
Issue number1141
DOIs
Publication statusPublished - 1 Nov 2020
Externally publishedYes

Keywords

  • all-cause mortality
  • cardiovascular mortality
  • obesity
  • uric acid

ASJC Scopus subject areas

  • Medicine(all)

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