Relationship between intravoxel incoherent motion diffusion-weighted MRI and dynamic contrast-enhanced MRI in tissue perfusion of cervical cancers

Elaine Yuen Phin Lee (Corresponding Author), Edward Sai Kam Hui, Karen Kar Loen Chan, Ka Yu Tse, Wai Kay Kwong, Tien Yee Chang, Queenie Chan, Pek Lan Khong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

45 Citations (Scopus)

Abstract

Purpose To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) in cervical cancer perfusion. Materials and Methods Prospective newly diagnosed cervical cancer patients underwent diffusion-weighted MRI (13 b-values: 1-1000 s/mm2) and DCE-MRI. The IVIM perfusion parameters, perfusion fraction (f), pseudodiffusion coefficient (D∗), and flow-related parameter (fD∗), were derived from a biexponential decay model. DCE-MRI was analyzed with a pharmacokinetic model and signal-time curve to derive the amplitude factor (A), estimated volume transfer constant between blood plasma, and the extravascular extracellular space (estKtrans), maximum relative enhancement (MaxRE), and area under the signal-time curve (AUC). Spearman's rank correlation coefficient (r) evaluated the correlative relationships. Results The f = 13.51%-±-1.76%, D∗ = 71.72-±-7.55 × 10-3 mm2/s, fD∗ = 9.64-±-1.28 × 10-3 mm2/s, A = 1.41-±-0.43, estKtrans = 0.19-±-0.06 s-1, MaxRE of 120.02-±-21.07%, and AUC 212,393-±-54,423 was found in 25 cervical cancer patients. Statistically significant positive correlations were found between fD∗ and estKtrans (r = 0.42, P = 0.038), fD∗ and A (r = 0.50, P = 0.011), fD∗ and MaxRE (r = 0.52, P = 0.008), f and AUC (r = 0.58, P = 0.003). Conclusion: The IVIM perfusion parameters showed moderate to good correlations with quantitative and semiquantitative perfusion parameters derived from DCE-MRI in cervical cancer.

Original languageEnglish
Pages (from-to)454-459
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Aug 2015
Externally publishedYes

Keywords

  • cervical cancer
  • DCE-MRI
  • intravoxel incoherent motion
  • IVIM
  • perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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