Refractive index measurement of single living cells using on-chip Fabry-Ṕrot cavity

W. Z. Song; Xuming Zhang; A. Q. Liu; C. S. Lim; P. H. Yap; Habib Mir M Hosseini

doi:10.1063/1.2387965

Refractive index measurement of single living cells using on-chip Fabry-Ṕrot cavity

W. Z. Song, Xuming Zhang, A. Q. Liu, C. S. Lim, P. H. Yap, Habib Mir M Hosseini

Research output: Journal article publication › Journal article › Academic research › peer-review

137 Citations (Scopus)

Abstract

This letter reports the measurement of single living cells' refractive index (RI) using an on-chip fiber-based Fabry-Ṕrot cavity by a differential method. In experiment a single cell is captured into the cavity, then the spectral shift in response to the buffer change and the cell presence/absence can be used to determine the cell's RI and size. Experiment on kidney cancer cells measures an effective RI of 1.399 at 0.1% accuracy. Compared with other approaches, the differential method eliminates uncertain factors and thus ensures high accuracy. The microchip facilitates automatic detection and makes it promising for label-free drug screening.

Original language	English
Article number	203901
Journal	Applied Physics Letters
Volume	89
Issue number	20
DOIs	https://doi.org/10.1063/1.2387965
Publication status	Published - 23 Nov 2006
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/1.2387965

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title = "Refractive index measurement of single living cells using on-chip Fabry-Ṕrot cavity",

abstract = "This letter reports the measurement of single living cells' refractive index (RI) using an on-chip fiber-based Fabry-Ṕrot cavity by a differential method. In experiment a single cell is captured into the cavity, then the spectral shift in response to the buffer change and the cell presence/absence can be used to determine the cell's RI and size. Experiment on kidney cancer cells measures an effective RI of 1.399 at 0.1% accuracy. Compared with other approaches, the differential method eliminates uncertain factors and thus ensures high accuracy. The microchip facilitates automatic detection and makes it promising for label-free drug screening.",

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AU - Yap, P. H.

AU - Hosseini, Habib Mir M

PY - 2006/11/23

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N2 - This letter reports the measurement of single living cells' refractive index (RI) using an on-chip fiber-based Fabry-Ṕrot cavity by a differential method. In experiment a single cell is captured into the cavity, then the spectral shift in response to the buffer change and the cell presence/absence can be used to determine the cell's RI and size. Experiment on kidney cancer cells measures an effective RI of 1.399 at 0.1% accuracy. Compared with other approaches, the differential method eliminates uncertain factors and thus ensures high accuracy. The microchip facilitates automatic detection and makes it promising for label-free drug screening.

AB - This letter reports the measurement of single living cells' refractive index (RI) using an on-chip fiber-based Fabry-Ṕrot cavity by a differential method. In experiment a single cell is captured into the cavity, then the spectral shift in response to the buffer change and the cell presence/absence can be used to determine the cell's RI and size. Experiment on kidney cancer cells measures an effective RI of 1.399 at 0.1% accuracy. Compared with other approaches, the differential method eliminates uncertain factors and thus ensures high accuracy. The microchip facilitates automatic detection and makes it promising for label-free drug screening.

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Refractive index measurement of single living cells using on-chip Fabry-Ṕrot cavity

Abstract

ASJC Scopus subject areas

UN SDGs

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