Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions

W. K.Jacky Lam; Ann D. King; Jacob A. Miller; Zhiwei Liu; Kelly J. Yu; Melvin L.K. Chua; Brigette B.Y. Ma; Ming Yuan Chen; Benjamin A. Pinsky; Pei Jen Lou; John K.S. Woo; Wan Lun Hsu; Julia Simon; Denise L. Doolan; Tim Waterboer; Edwin P. Hui; Hui Li; Raymond K. Tsang; Kenneth C.W. Wong; Julian P. Goh; Alexander C. Vlantis; Qi Yong Ai; Lun M. Wong; Victor Abdullah; Jin Ching Lin; Chien Jen Chen; Ruth M. Pfeiffer; Quynh Thu Le; Anne W.M. Lee; Mingfang Ji; Sumei Cao; Jun Ma; Anthony T.C. Chan; K. C.Allen Chan; Allan Hildesheim

doi:10.1093/jnci/djad012

Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions

W. K.Jacky Lam, Ann D. King, Jacob A. Miller, Zhiwei Liu, Kelly J. Yu, Melvin L.K. Chua, Brigette B.Y. Ma, Ming Yuan Chen, Benjamin A. Pinsky, Pei Jen Lou, John K.S. Woo, Wan Lun Hsu, Julia Simon, Denise L. Doolan, Tim Waterboer, Edwin P. Hui, Hui Li, Raymond K. Tsang, Kenneth C.W. Wong, Julian P. GohAlexander C. Vlantis, Qi Yong Ai, Lun M. Wong, Victor Abdullah, Jin Ching Lin, Chien Jen Chen, Ruth M. Pfeiffer, Quynh Thu Le, Anne W.M. Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T.C. Chan, K. C.Allen Chan, Allan Hildesheim

Department of Health Technology and Informatics

Research output: Journal article publication › Journal article › Academic research › peer-review

32 Citations (Scopus)

Abstract

A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

Original language	English
Pages (from-to)	355-364
Number of pages	10
Journal	Journal of the National Cancer Institute
Volume	115
Issue number	4
DOIs	https://doi.org/10.1093/jnci/djad012
Publication status	Published - 11 Apr 2023

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1093/jnci/djad012

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Lam, W. K. J., King, A. D., Miller, J. A., Liu, Z., Yu, K. J., Chua, M. L. K., Ma, B. B. Y., Chen, M. Y., Pinsky, B. A., Lou, P. J., Woo, J. K. S., Hsu, W. L., Simon, J., Doolan, D. L., Waterboer, T., Hui, E. P., Li, H., Tsang, R. K., Wong, K. C. W., ... Hildesheim, A. (2023). Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions. Journal of the National Cancer Institute, 115(4), 355-364. https://doi.org/10.1093/jnci/djad012

@article{805110be29874ec0975a58b6260209bc,

title = "Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions",

abstract = "A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.",

author = "Lam, \{W. K.Jacky\} and King, \{Ann D.\} and Miller, \{Jacob A.\} and Zhiwei Liu and Yu, \{Kelly J.\} and Chua, \{Melvin L.K.\} and Ma, \{Brigette B.Y.\} and Chen, \{Ming Yuan\} and Pinsky, \{Benjamin A.\} and Lou, \{Pei Jen\} and Woo, \{John K.S.\} and Hsu, \{Wan Lun\} and Julia Simon and Doolan, \{Denise L.\} and Tim Waterboer and Hui, \{Edwin P.\} and Hui Li and Tsang, \{Raymond K.\} and Wong, \{Kenneth C.W.\} and Goh, \{Julian P.\} and Vlantis, \{Alexander C.\} and Ai, \{Qi Yong\} and Wong, \{Lun M.\} and Victor Abdullah and Lin, \{Jin Ching\} and Chen, \{Chien Jen\} and Pfeiffer, \{Ruth M.\} and Le, \{Quynh Thu\} and Lee, \{Anne W.M.\} and Mingfang Ji and Sumei Cao and Jun Ma and Chan, \{Anthony T.C.\} and Chan, \{K. C.Allen\} and Allan Hildesheim",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press.",

year = "2023",

month = apr,

day = "11",

doi = "10.1093/jnci/djad012",

language = "English",

volume = "115",

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journal = "Journal of the National Cancer Institute",

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Lam, WKJ, King, AD, Miller, JA, Liu, Z, Yu, KJ, Chua, MLK, Ma, BBY, Chen, MY, Pinsky, BA, Lou, PJ, Woo, JKS, Hsu, WL, Simon, J, Doolan, DL, Waterboer, T, Hui, EP, Li, H, Tsang, RK, Wong, KCW, Goh, JP, Vlantis, AC, Ai, QY, Wong, LM, Abdullah, V, Lin, JC, Chen, CJ, Pfeiffer, RM, Le, QT, Lee, AWM, Ji, M, Cao, S, Ma, J, Chan, ATC, Chan, KCA & Hildesheim, A 2023, 'Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions', Journal of the National Cancer Institute, vol. 115, no. 4, pp. 355-364. https://doi.org/10.1093/jnci/djad012

TY - JOUR

T1 - Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions

AU - Lam, W. K.Jacky

AU - King, Ann D.

AU - Miller, Jacob A.

AU - Liu, Zhiwei

AU - Yu, Kelly J.

AU - Chua, Melvin L.K.

AU - Ma, Brigette B.Y.

AU - Chen, Ming Yuan

AU - Pinsky, Benjamin A.

AU - Lou, Pei Jen

AU - Woo, John K.S.

AU - Hsu, Wan Lun

AU - Simon, Julia

AU - Doolan, Denise L.

AU - Waterboer, Tim

AU - Hui, Edwin P.

AU - Li, Hui

AU - Tsang, Raymond K.

AU - Wong, Kenneth C.W.

AU - Goh, Julian P.

AU - Vlantis, Alexander C.

AU - Ai, Qi Yong

AU - Wong, Lun M.

AU - Abdullah, Victor

AU - Lin, Jin Ching

AU - Chen, Chien Jen

AU - Pfeiffer, Ruth M.

AU - Le, Quynh Thu

AU - Lee, Anne W.M.

AU - Ji, Mingfang

AU - Cao, Sumei

AU - Ma, Jun

AU - Chan, Anthony T.C.

AU - Chan, K. C.Allen

AU - Hildesheim, Allan

PY - 2023/4/11

Y1 - 2023/4/11

N2 - A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

AB - A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

UR - https://www.scopus.com/pages/publications/85152169320

U2 - 10.1093/jnci/djad012

DO - 10.1093/jnci/djad012

M3 - Journal article

C2 - 36723440

AN - SCOPUS:85152169320

SN - 0027-8874

VL - 115

SP - 355

EP - 364

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 4

ER -

Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions

Abstract

ASJC Scopus subject areas

UN SDGs

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