Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions

W. K.Jacky Lam, Ann D. King, Jacob A. Miller, Zhiwei Liu, Kelly J. Yu, Melvin L.K. Chua, Brigette B.Y. Ma, Ming Yuan Chen, Benjamin A. Pinsky, Pei Jen Lou, John K.S. Woo, Wan Lun Hsu, Julia Simon, Denise L. Doolan, Tim Waterboer, Edwin P. Hui, Hui Li, Raymond K. Tsang, Kenneth C.W. Wong, Julian P. GohAlexander C. Vlantis, Qi Yong Ai, Lun M. Wong, Victor Abdullah, Jin Ching Lin, Chien Jen Chen, Ruth M. Pfeiffer, Quynh Thu Le, Anne W.M. Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T.C. Chan, K. C.Allen Chan, Allan Hildesheim

Research output: Journal article publicationJournal articleAcademic researchpeer-review

18 Citations (Scopus)

Abstract

A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

Original languageEnglish
Pages (from-to)355-364
Number of pages10
JournalJournal of the National Cancer Institute
Volume115
Issue number4
DOIs
Publication statusPublished - 11 Apr 2023

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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