TY - JOUR
T1 - Recent advances of cellular stimulation with triboelectric nanogenerators
AU - Zhou, Xingyu
AU - Li, Gaocai
AU - Wu, Di
AU - Liang, Huaizhen
AU - Zhang, Weifeng
AU - Zeng, Lingli
AU - Zhu, Qianqian
AU - Lai, Puxiang
AU - Wen, Zhen
AU - Yang, Cao
AU - Pan, Yue
N1 - Publisher Copyright:
© 2023 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.
PY - 2023/8
Y1 - 2023/8
N2 - Triboelectric nanogenerators (TENGs) are new energy collection devices that have the characteristics of high efficiency, low cost, miniaturization capability, and convenient manufacture. TENGs mainly utilize the triboelectric effect to obtain mechanical energy from organisms or the environment, and this mechanical energy is then converted into and output as electrical energy. Bioelectricity is a phenomenon that widely exists in various cellular processes, including cell proliferation, senescence, apoptosis, as well as adjacent cells’ communication and coordination. Therefore, based on these features, TENGs can be applied in organisms to collect energy and output electrical stimulation to act on cells, changing their activities and thereby playing a role in regulating cellular function and interfering with cellular fate, which can further develop into new methods of health care and disease intervention. In this review, we first introduce the working principle of TENGs and their working modes, and then summarize the current research status of cellular function regulation and fate determination stimulated by TENGs, and also analyze their application prospects for changing various processes of cell activity. Finally, we discuss the opportunities and challenges of TENGs in the fields of life science and biomedical engineering, and propose a variety of possibilities for their potential development direction.
AB - Triboelectric nanogenerators (TENGs) are new energy collection devices that have the characteristics of high efficiency, low cost, miniaturization capability, and convenient manufacture. TENGs mainly utilize the triboelectric effect to obtain mechanical energy from organisms or the environment, and this mechanical energy is then converted into and output as electrical energy. Bioelectricity is a phenomenon that widely exists in various cellular processes, including cell proliferation, senescence, apoptosis, as well as adjacent cells’ communication and coordination. Therefore, based on these features, TENGs can be applied in organisms to collect energy and output electrical stimulation to act on cells, changing their activities and thereby playing a role in regulating cellular function and interfering with cellular fate, which can further develop into new methods of health care and disease intervention. In this review, we first introduce the working principle of TENGs and their working modes, and then summarize the current research status of cellular function regulation and fate determination stimulated by TENGs, and also analyze their application prospects for changing various processes of cell activity. Finally, we discuss the opportunities and challenges of TENGs in the fields of life science and biomedical engineering, and propose a variety of possibilities for their potential development direction.
KW - bioelectricity
KW - cellular fate determination
KW - cellular function regulation
KW - electrical stimulation
KW - triboelectric nanogenerators
UR - http://www.scopus.com/inward/record.url?scp=85177804838&partnerID=8YFLogxK
U2 - 10.1002/EXP.20220090
DO - 10.1002/EXP.20220090
M3 - Review article
VL - 3
JO - Exploration
JF - Exploration
IS - 4
M1 - 20220090
ER -