Recent advances in two-dimensional transition metal dichalcogenide nanocomposites biosensors for virus detection before and during COVID-19 outbreak

Ching Ying Katherine Lam, Qin Zhang, Bohan Yin, Yingying Huang, Hui Wang, Mo Yang, Siu Hong Dexter Wong

Research output: Journal article publicationReview articleAcademic researchpeer-review

1 Citation (Scopus)


The deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak has become one of the most challenging pandemics in the last century. Clinical diagnosis reports a high infection rate within a large population and a rapid mutation rate upon every individual infection. The polymerase chain reaction has been a powerful and gold standard molecular diagnostic technique over the past few decades and hence a promising tool to detect the SARS-CoV-2 nucleic acid sequences. However, it can be costly and involved in complicated processes with a high demand for on-site tests. This pandemic emphasizes the critical need for designing cost-effective and fast diagnosis strategies to prevent a potential viral source by ultrasensitive and selective biosensors. Two-dimensional (2D) transition metal dichalcogenide (TMD) nanocomposites have been developed with unique physical and chemical properties crucial for building up nucleic acid and protein biosensors. In this review, we cover various types of 2D TMD biosensors available for virus detection via the mechanisms of photoluminescence/optical, field-effect transistor, surface plasmon resonance, and electrochemical signals. We summarize the current state-of-the-art applications of 2D TMD nanocomposite systems for sensing proteins/nucleic acid from different types of lethal viruses. Finally, we identify and discuss the advantages and limitations of TMD-based nanocomposites biosensors for viral recognition.

Original languageEnglish
Pages (from-to)190
Number of pages1
JournalJournal of Composites Science
Issue number7
Publication statusPublished - Jul 2021


  • Biosensors
  • Nanocomposites
  • SARS-CoV-2
  • Transition metal dichalcogenide

ASJC Scopus subject areas

  • Ceramics and Composites
  • Engineering (miscellaneous)

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