Recent Advances in Engineering Carriers for siRNA Delivery

Chengbin Yang (Corresponding Author), Zheng Ian Lin, Xinmeng Zhang, Zhourui Xu, Gaixia Xu, Yu Min Wang, Tzu Hsien Tsai, Pei Wen Cheng, Wing Cheung Law, Ken Tye Yong, Chih Kuang Chen (Corresponding Author)

Research output: Journal article publicationReview articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

RNA interference (RNAi) technology has been a promising treatment strategy for combating intractable diseases. However, the applications of RNAi in clinical are hampered by extracellular and intracellular barriers. To overcome these barriers, various siRNA delivery systems have been developed in the past two decades. The first approved RNAi therapeutic, Patisiran (ONPATTRO) using lipids as the carrier, for the treatment of amyloidosis is one of the most important milestones. This has greatly encouraged researchers to work on creating new functional siRNA carriers. In this review, the recent advances in siRNA carriers consisting of lipids, polymers, and polymer-modified inorganic particles for cancer therapy are summarized. Representative examples are presented to show the structural design of the carriers in order to overcome the delivery hurdles associated with RNAi therapies. Finally, the existing challenges and future perspective for developing RNAi as a clinical modality will be discussed and proposed. It is believed that the addressed contributions in this review will promote the development of siRNA delivery systems for future clinical applications.

Original languageEnglish
Article number2300362
Number of pages39
JournalMacromolecular Bioscience
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 2024

Keywords

  • cationic natural polymers
  • cationic synthetic polymers
  • gene therapy
  • lipids
  • polymer-modified inorganic nanoparticles
  • siRNA delivery

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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