Real-time measurement of cellular refractive index and thickness using cell culture chip

J. J. Gu; Y. F. Yu; E. P. Li; S. H. Ng; P. H. Yap; X. Q. Zhou; T. H. Cheng; A. Q. Liu

Real-time measurement of cellular refractive index and thickness using cell culture chip

J. J. Gu, Y. F. Yu, E. P. Li, S. H. Ng, P. H. Yap, X. Q. Zhou, T. H. Cheng, A. Q. Liu

Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review

4 Citations (Scopus)

Abstract

This paper reports the measurement of refractive index (RI) and thickness of living cells using cell culture chip integrated with micro-indicators via immersion refractometry. In the experiment, the RI and the thickness of the cultured Madin-Darby canine kidney (MDCK) cell line are obtained simultaneously. As this method features high accuracy, no damage to a group of the living cells and real time measurement during long-term cell culture, it is promising for many applications such as detecting pathological changes of cells and cancer cell detection.

Original language	English
Pages	1873-1875
Number of pages	3
Publication status	Published - Oct 2008
Externally published	Yes
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 12 Oct 2008 → 16 Oct 2008

Conference

Conference	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	12/10/08 → 16/10/08

Keywords

Cell culture
Immersion refractometry
Lab-on-a-chip
Refractive index

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Real-time measurement of cellular refractive index and thickness using cell culture chip",

abstract = "This paper reports the measurement of refractive index (RI) and thickness of living cells using cell culture chip integrated with micro-indicators via immersion refractometry. In the experiment, the RI and the thickness of the cultured Madin-Darby canine kidney (MDCK) cell line are obtained simultaneously. As this method features high accuracy, no damage to a group of the living cells and real time measurement during long-term cell culture, it is promising for many applications such as detecting pathological changes of cells and cancer cell detection.",

keywords = "Cell culture, Immersion refractometry, Lab-on-a-chip, Refractive index",

author = "Gu, {J. J.} and Yu, {Y. F.} and Li, {E. P.} and Ng, {S. H.} and Yap, {P. H.} and Zhou, {X. Q.} and Cheng, {T. H.} and Liu, {A. Q.}",

year = "2008",

month = oct,

language = "English",

pages = "1873--1875",

note = "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 ; Conference date: 12-10-2008 Through 16-10-2008",

}

Real-time measurement of cellular refractive index and thickness using cell culture chip. / Gu, J. J.; Yu, Y. F.; Li, E. P. et al.
2008. 1873-1875 Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.

Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review

TY - CONF

T1 - Real-time measurement of cellular refractive index and thickness using cell culture chip

AU - Gu, J. J.

AU - Yu, Y. F.

AU - Li, E. P.

AU - Ng, S. H.

AU - Yap, P. H.

AU - Zhou, X. Q.

AU - Cheng, T. H.

AU - Liu, A. Q.

PY - 2008/10

Y1 - 2008/10

N2 - This paper reports the measurement of refractive index (RI) and thickness of living cells using cell culture chip integrated with micro-indicators via immersion refractometry. In the experiment, the RI and the thickness of the cultured Madin-Darby canine kidney (MDCK) cell line are obtained simultaneously. As this method features high accuracy, no damage to a group of the living cells and real time measurement during long-term cell culture, it is promising for many applications such as detecting pathological changes of cells and cancer cell detection.

AB - This paper reports the measurement of refractive index (RI) and thickness of living cells using cell culture chip integrated with micro-indicators via immersion refractometry. In the experiment, the RI and the thickness of the cultured Madin-Darby canine kidney (MDCK) cell line are obtained simultaneously. As this method features high accuracy, no damage to a group of the living cells and real time measurement during long-term cell culture, it is promising for many applications such as detecting pathological changes of cells and cancer cell detection.

KW - Cell culture

KW - Immersion refractometry

KW - Lab-on-a-chip

KW - Refractive index

UR - http://www.scopus.com/inward/record.url?scp=84902449565&partnerID=8YFLogxK

M3 - Conference presentation (not published in journal/proceeding/book)

AN - SCOPUS:84902449565

SP - 1873

EP - 1875

T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Real-time measurement of cellular refractive index and thickness using cell culture chip

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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