Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Setting, degradation and drug release considerations

Xin Zhao, Irwin Olsen, Jonathan Pratten, Jonathan C. Knowles, Anne M. Young

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)

Abstract

This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-copropylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity.
Original languageEnglish
Pages (from-to)1993-2004
Number of pages12
JournalJournal of Materials Science: Materials in Medicine
Volume22
Issue number9
DOIs
Publication statusPublished - 1 Sep 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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