Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Setting, degradation and drug release considerations

Xin Zhao; Irwin Olsen; Jonathan Pratten; Jonathan C. Knowles; Anne M. Young

doi:10.1007/s10856-011-4378-4

Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Setting, degradation and drug release considerations

Xin Zhao, Irwin Olsen, Jonathan Pratten, Jonathan C. Knowles, Anne M. Young

Research output: Journal article publication › Journal article › Academic research › peer-review

8 Citations (Scopus)

Abstract

This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-copropylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity.

Original language	English
Pages (from-to)	1993-2004
Number of pages	12
Journal	Journal of Materials Science: Materials in Medicine
Volume	22
Issue number	9
DOIs	https://doi.org/10.1007/s10856-011-4378-4
Publication status	Published - 1 Sept 2011
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1007/s10856-011-4378-4

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abstract = "This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-copropylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity.",

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Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Setting, degradation and drug release considerations. / Zhao, Xin; Olsen, Irwin; Pratten, Jonathan et al.
In: Journal of Materials Science: Materials in Medicine, Vol. 22, No. 9, 01.09.2011, p. 1993-2004.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Zhao, Xin

AU - Olsen, Irwin

AU - Pratten, Jonathan

AU - Knowles, Jonathan C.

AU - Young, Anne M.

PY - 2011/9/1

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AB - This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-copropylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity.

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Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Setting, degradation and drug release considerations

Abstract

ASJC Scopus subject areas

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