Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Chemical, mechanical and biological considerations

Xin Zhao, Irwin Olsen, Haoying Li, Kris Gellynck, Paul G. Buxton, Jonathan C. Knowles, Vehid Salih, Anne M. Young

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)

Abstract

A poly(propylene glycol-co-lactide) dimethacrylate adhesive with monocalcium phosphate monohydrate (MCPM)/β-tricalcium phosphate (β-TCP) fillers in various levels has been investigated. Water sorption by the photo-polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP). Polymer modulus was found to be enhanced upon raising total calcium phosphate content. With greater DCP levels, faster release of phosphate and calcium ions and improved buffering of polymer degradation products were observed. This could reduce the likelihood of pH-catalyzed bulk degradation and localized acid production and thereby may prevent adverse biological responses. Bone-like MG-63 cells were found to attach, spread and have normal morphology on both the polymer and composite surfaces. Moreover, composites implanted into chick embryo femurs became closely apposed to the host tissue and did not appear to induce adverse immunological reaction. The above results suggest that the new composite materials hold promise as clinical effective bone adhesives.
Original languageEnglish
Pages (from-to)845-855
Number of pages11
JournalActa Biomaterialia
Volume6
Issue number3
DOIs
Publication statusPublished - 1 Mar 2010
Externally publishedYes

Keywords

  • Biocompatibility
  • Bone repair
  • Calcium phosphate
  • Mechanical properties
  • Poly(propylene glycol-co-lactide) dimethacrylate

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering
  • Molecular Biology

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