TY - JOUR
T1 - Rate and risk factors of depressive symptoms in Chinese patients presenting with first-episode non-affective psychosis in Hong Kong
AU - Chang, Wing Chung
AU - Cheung, Rowan
AU - Hui, Christy Lai Ming
AU - Lin, Jingxia
AU - Chan, Sherry Kit Wa
AU - Lee, Edwin Ho Ming
AU - Chen, Eric Yu Hai
N1 - Funding Information:
This study was funded by the Hong Kong Jockey Club Charities Trust ( 21009144 ). The funding body had no involvement in any aspect of the study or manuscript preparation.
Funding Information:
Author E.Y.H.C. has participated in the paid advisory board for Otsuka, has received educational grant support from Janssen-Cilag, and has received research funding from Astra-Zeneca, Janssen-Cilag, Eli Lilly, Sanofi-Aventis and Otsuka. E.H.M.L. has been a member of the paid advisory boards for Eli Lilly and AstraZeneca. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Publisher Copyright:
© 2015 Elsevier B.V.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background: Depressive symptoms are a distinct symptom dimension in psychotic disorders and are associated with elevated suicide risk, and poorer clinical and functional outcomes. Previous research on depressive symptoms mainly focused on chronic patients and few studies were conducted to investigate factors associated with depression in the early illness course. We aimed to examine the prevalence and risk factors of depressive symptoms, and their impacts on functioning, subjective quality of life (QoL) and self-efficacy in first-episode non-affective psychosis. Method: Three hundred fifty-one Hong Kong Chinese aged 26-55. years presenting with first-episode non-affective psychosis to early intervention service were recruited. Assessments encompassing sociodemographics, premorbid adjustment, clinical and treatment profiles, functioning, QoL and perceived self-efficacy were conducted. Patients who had Calgary Depression Scale for Schizophrenia (CDSS) total score ≥. 6 were classified as having depressive symptoms. Results: Fifty-three (15.1%) patients exhibited depressive symptoms at entry. Depressed patients had worse functioning, poorer QoL and lower level of self-efficacy than non-depressed counterparts. Multivariate regression analysis showed that previous exposure to stressful life events, unemployment, being married, more severe positive symptoms, higher level of antipsychotic-induced Parkinsonism and negative attitude towards medication treatment were independently associated with depression status. Conclusions: Depressive symptoms were frequently observed in adult patients with first-episode nonaffective psychosis, and were linked to poor functioning and QoL. Our findings indicated that, aside from social and clinical risk factors, presence of drug-induced Parkinsonism and negative treatment attitude may render patients more vulnerable to developing depression in the early stage of psychotic illness.
AB - Background: Depressive symptoms are a distinct symptom dimension in psychotic disorders and are associated with elevated suicide risk, and poorer clinical and functional outcomes. Previous research on depressive symptoms mainly focused on chronic patients and few studies were conducted to investigate factors associated with depression in the early illness course. We aimed to examine the prevalence and risk factors of depressive symptoms, and their impacts on functioning, subjective quality of life (QoL) and self-efficacy in first-episode non-affective psychosis. Method: Three hundred fifty-one Hong Kong Chinese aged 26-55. years presenting with first-episode non-affective psychosis to early intervention service were recruited. Assessments encompassing sociodemographics, premorbid adjustment, clinical and treatment profiles, functioning, QoL and perceived self-efficacy were conducted. Patients who had Calgary Depression Scale for Schizophrenia (CDSS) total score ≥. 6 were classified as having depressive symptoms. Results: Fifty-three (15.1%) patients exhibited depressive symptoms at entry. Depressed patients had worse functioning, poorer QoL and lower level of self-efficacy than non-depressed counterparts. Multivariate regression analysis showed that previous exposure to stressful life events, unemployment, being married, more severe positive symptoms, higher level of antipsychotic-induced Parkinsonism and negative attitude towards medication treatment were independently associated with depression status. Conclusions: Depressive symptoms were frequently observed in adult patients with first-episode nonaffective psychosis, and were linked to poor functioning and QoL. Our findings indicated that, aside from social and clinical risk factors, presence of drug-induced Parkinsonism and negative treatment attitude may render patients more vulnerable to developing depression in the early stage of psychotic illness.
KW - Depressive symptoms
KW - First-episode psychosis
KW - Negative treatment attitude
KW - Prevalence
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=84942363790&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2015.07.040
DO - 10.1016/j.schres.2015.07.040
M3 - Journal article
C2 - 26235752
AN - SCOPUS:84942363790
SN - 0920-9964
VL - 168
SP - 99
EP - 105
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-2
M1 - 6517
ER -
