Rapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation

Siucheong Yan; Iris L.K. Wong; Ming Cheung Chow; Hongzhe Sun

doi:10.1039/b210240d

Rapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation

Siucheong Yan, Iris L.K. Wong, Ming Cheung Chow, Hongzhe Sun

Research output: Journal article publication › Journal article › Academic research › peer-review

25 Citations (Scopus)

Abstract

The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

Original language	English
Pages (from-to)	266-267
Number of pages	2
Journal	Chemical Communications
Issue number	2
DOIs	https://doi.org/10.1039/b210240d
Publication status	Published - 3 Feb 2003

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b210240d

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title = "Rapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation",

abstract = "The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.",

author = "Siucheong Yan and Wong, {Iris L.K.} and Chow, {Ming Cheung} and Hongzhe Sun",

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AU - Yan, Siucheong

AU - Wong, Iris L.K.

AU - Chow, Ming Cheung

AU - Sun, Hongzhe

PY - 2003/2/3

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N2 - The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

AB - The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

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U2 - 10.1039/b210240d

DO - 10.1039/b210240d

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SP - 266

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Rapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation

Abstract

ASJC Scopus subject areas

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