Rapid detection of drugs-of-abuse in urine and oral fluid by mass spectrometry

Tsz Tsun Ng, Bin Hu, Pui Kin So, Zhongping Yao

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Development of simple, reliable and cost-effective methods for drug analysis is crucial for the fight against drug abuse. In order to deal with large number of samples, preliminary screening is normally firstly applied, followed by confirmatory analysis. However, the preliminary screening, which involves the use of testing kits, has the problem of producing false positive or false negative results, while the confirmatory analysis is time-consuming and laborious as extensive sample pretreatment and chromatographic separation process are required. To solve these problems, we have developed two techniques, i.e., wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS) and solid phase microextraction coupled with electrospray ionization mass spectrometry (SPME-ESI-MS), for rapid and reliable detection of common drugs-of-abuse in human urine and oral fluid.
Original languageEnglish
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2017
PublisherTechConnect
Pages261-263
Number of pages3
Volume3
ISBN (Electronic)9780998878201
Publication statusPublished - 1 Jan 2017
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
Duration: 14 May 201717 May 2017

Conference

Conference11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
Country/TerritoryUnited States
CityWashington
Period14/05/1717/05/17

Keywords

  • Ambient inoization
  • Drug analysis
  • Solid phase microextraction
  • Wooden-tip electrospray ionization mass spectrometry

ASJC Scopus subject areas

  • Fuel Technology
  • Surfaces, Coatings and Films
  • Biotechnology
  • Fluid Flow and Transfer Processes

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