Radiation induced temporal lobe necrosis in nasopharyngeal cancer patients after radical external beam radiotherapy

Vincent W.C. Wu; Shing Yau Tam

doi:10.1186/s13014-020-01560-0

Radiation induced temporal lobe necrosis in nasopharyngeal cancer patients after radical external beam radiotherapy

Vincent W.C. Wu, Shing Yau Tam

Research output: Journal article publication › Review article › Academic research › peer-review

7 Citations (Scopus)

Abstract

Radiation-induced temporal lobe necrosis (TLN) is one of the late post-radiotherapy complications in nasopharyngeal cancer (NPC) patients. Since NPC is common to have skull base infiltration, irradiation of the temporal lobes is inevitable despite the use of the more advanced intensity-modulated radiotherapy (IMRT). Moreover, the diagnosis and treatment of TLN remain challenging. In this review, we discuss the diagnosis of TLN with conventional and advanced imaging modalities, onset and predictive parameters of TLN development, the impact of IMRT on TLN in terms of incidence and dosimetric analyzes, and the recent advancements in the treatment of TLN.

Original language	English
Number of pages	1
Journal	Radiation oncology (London, England)
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s13014-020-01560-0
Publication status	Published - 15 May 2020

Keywords

Diagnosis and treatment
Nasopharyngeal carcinoma
Radiation induced complication
Radiotherapy
Temporal lobe necrosis

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13014-020-01560-0

http://hdl.handle.net/10397/87832

Cite this

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title = "Radiation induced temporal lobe necrosis in nasopharyngeal cancer patients after radical external beam radiotherapy",

abstract = "Radiation-induced temporal lobe necrosis (TLN) is one of the late post-radiotherapy complications in nasopharyngeal cancer (NPC) patients. Since NPC is common to have skull base infiltration, irradiation of the temporal lobes is inevitable despite the use of the more advanced intensity-modulated radiotherapy (IMRT). Moreover, the diagnosis and treatment of TLN remain challenging. In this review, we discuss the diagnosis of TLN with conventional and advanced imaging modalities, onset and predictive parameters of TLN development, the impact of IMRT on TLN in terms of incidence and dosimetric analyzes, and the recent advancements in the treatment of TLN.",

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T1 - Radiation induced temporal lobe necrosis in nasopharyngeal cancer patients after radical external beam radiotherapy

AU - Wu, Vincent W.C.

AU - Tam, Shing Yau

PY - 2020/5/15

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N2 - Radiation-induced temporal lobe necrosis (TLN) is one of the late post-radiotherapy complications in nasopharyngeal cancer (NPC) patients. Since NPC is common to have skull base infiltration, irradiation of the temporal lobes is inevitable despite the use of the more advanced intensity-modulated radiotherapy (IMRT). Moreover, the diagnosis and treatment of TLN remain challenging. In this review, we discuss the diagnosis of TLN with conventional and advanced imaging modalities, onset and predictive parameters of TLN development, the impact of IMRT on TLN in terms of incidence and dosimetric analyzes, and the recent advancements in the treatment of TLN.

AB - Radiation-induced temporal lobe necrosis (TLN) is one of the late post-radiotherapy complications in nasopharyngeal cancer (NPC) patients. Since NPC is common to have skull base infiltration, irradiation of the temporal lobes is inevitable despite the use of the more advanced intensity-modulated radiotherapy (IMRT). Moreover, the diagnosis and treatment of TLN remain challenging. In this review, we discuss the diagnosis of TLN with conventional and advanced imaging modalities, onset and predictive parameters of TLN development, the impact of IMRT on TLN in terms of incidence and dosimetric analyzes, and the recent advancements in the treatment of TLN.

KW - Diagnosis and treatment

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KW - Radiation induced complication

KW - Radiotherapy

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M3 - Review article

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JF - Radiation Oncology

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Radiation induced temporal lobe necrosis in nasopharyngeal cancer patients after radical external beam radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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