Quinolizinium-based tunable pH fluorescent probes for imaging in live cells

Hoi Yi Sit, Jie Ren Deng, Wing Cheung Chan, Ben Chi Bun Ko, Man Kin Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)


A new class of quinolizinium-based tunable pH fluorescent probes for cell imaging was developed. The probes showed turn “On” fluorescence response upon acidification brought by a modulation of photoinduced electron transfer (PET) from the N,N-dialkyl aniline substituent to the quinolizinium core skeleton. These novel PET-based pH fluorescent probes displayed tunable emission properties in between 478 and 509 nm. Also, the probes exhibited tunable pH responsiveness with pKa ranging from <2.1 to 6.1 contributed by the steric effect of N,N-dialkyl anilines. They were successfully applied to in vivo pH sensing in lysosome in live cells.

Original languageEnglish
Article number110541
JournalDyes and Pigments
Publication statusPublished - Sept 2022


  • Cellular imaging
  • pH probe
  • Photo-induced electron transfer
  • Quinolizinium

ASJC Scopus subject areas

  • General Chemical Engineering
  • Process Chemistry and Technology


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