Quinolizinium-based fluorescent probes for formaldehyde detection in aqueous solution, serum, and test strip via 2-aza-Cope rearrangement

Ajcharapan TANTIPANJAPORN, Ka Yan, Karen KUNG, Hoi Yi SIT, Man Kin WONG

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

Formaldehyde is an abundant contaminant in food and environments causing various diseases. Thus, the development of fast, simple, and selective formaldehyde detection is of great interest. Herein, novel quinolizinium-based fluorescent probes were designed based on a 2-aza-Cope rearrangement reaction and showed high selectivity to formaldehyde by fluorescence emission shift. We successfully reduced the detection time by increasing the bulkiness of the homoallylic moiety. The probes were applied to detect formaldehyde in aqueous solution, serum, and paper format.

Original languageEnglish
Pages (from-to)11543-11547
Number of pages5
JournalRSC Advances
Volume12
Issue number18
DOIs
Publication statusPublished - 13 Apr 2022

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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