TY - JOUR
T1 - Quantitative measurement of interocular suppression in anisometropic amblyopia
T2 - A case-control study
AU - Li, Jinrong
AU - Hess, Robert F.
AU - Chan, Lily Y.L.
AU - Deng, Daming
AU - Yang, Xiao
AU - Chen, Xiang
AU - Yu, Minbin
AU - Thompson, Benjamin
PY - 2013/8
Y1 - 2013/8
N2 - Objective: The aims of this study were to assess (1) the relationship between interocular suppression and visual function in patients with anisometropic amblyopia, (2) whether suppression can be simulated in matched controls using monocular defocus or neutral density filters, (3) the effects of spectacle or rigid gas-permeable contact lens correction on suppression in patients with anisometropic amblyopia, and (4) the relationship between interocular suppression and outcomes of occlusion therapy. Design: Case-control study (aims 1-3) and cohort study (aim 4). Participants: Forty-five participants with anisometropic amblyopia and 45 matched controls (mean age, 8.8 years for both groups). Methods: Interocular suppression was assessed using Bagolini striated lenses, neutral density filters, and an objective psychophysical technique that measures the amount of contrast imbalance between the 2 eyes that is required to overcome suppression (dichoptic motion coherence thresholds). Visual acuity was assessed using a logarithm minimum angle of resolution tumbling E chart and stereopsis using the Randot preschool test. Main Outcome Measures: Interocular suppression assessed using dichoptic motion coherence thresholds. Results: Patients exhibited significantly stronger suppression than controls, and stronger suppression was correlated significantly with poorer visual acuity in amblyopic eyes. Reducing monocular acuity in controls to match that of cases using neutral density filters (luminance reduction) resulted in levels of interocular suppression comparable with that in patients. This was not the case for monocular defocus (optical blur). Rigid gas-permeable contact lens correction resulted in less suppression than spectacle correction, and stronger suppression was associated with poorer outcomes after occlusion therapy. Conclusions: Interocular suppression plays a key role in the visual deficits associated with anisometropic amblyopia and can be simulated in controls by inducing a luminance difference between the eyes. Accurate quantification of suppression using the dichoptic motion coherence threshold technique may provide useful information for the management and treatment of anisometropic amblyopia.
AB - Objective: The aims of this study were to assess (1) the relationship between interocular suppression and visual function in patients with anisometropic amblyopia, (2) whether suppression can be simulated in matched controls using monocular defocus or neutral density filters, (3) the effects of spectacle or rigid gas-permeable contact lens correction on suppression in patients with anisometropic amblyopia, and (4) the relationship between interocular suppression and outcomes of occlusion therapy. Design: Case-control study (aims 1-3) and cohort study (aim 4). Participants: Forty-five participants with anisometropic amblyopia and 45 matched controls (mean age, 8.8 years for both groups). Methods: Interocular suppression was assessed using Bagolini striated lenses, neutral density filters, and an objective psychophysical technique that measures the amount of contrast imbalance between the 2 eyes that is required to overcome suppression (dichoptic motion coherence thresholds). Visual acuity was assessed using a logarithm minimum angle of resolution tumbling E chart and stereopsis using the Randot preschool test. Main Outcome Measures: Interocular suppression assessed using dichoptic motion coherence thresholds. Results: Patients exhibited significantly stronger suppression than controls, and stronger suppression was correlated significantly with poorer visual acuity in amblyopic eyes. Reducing monocular acuity in controls to match that of cases using neutral density filters (luminance reduction) resulted in levels of interocular suppression comparable with that in patients. This was not the case for monocular defocus (optical blur). Rigid gas-permeable contact lens correction resulted in less suppression than spectacle correction, and stronger suppression was associated with poorer outcomes after occlusion therapy. Conclusions: Interocular suppression plays a key role in the visual deficits associated with anisometropic amblyopia and can be simulated in controls by inducing a luminance difference between the eyes. Accurate quantification of suppression using the dichoptic motion coherence threshold technique may provide useful information for the management and treatment of anisometropic amblyopia.
UR - http://www.scopus.com/inward/record.url?scp=84881128734&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2013.01.048
DO - 10.1016/j.ophtha.2013.01.048
M3 - Journal article
C2 - 23622875
AN - SCOPUS:84881128734
SN - 0161-6420
VL - 120
SP - 1672
EP - 1680
JO - Ophthalmology
JF - Ophthalmology
IS - 8
ER -