Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Hao Yang; Xue Gou; Kar Hang Chu; Yong Wang; Dong Sun

doi:10.1109/NANO.2014.6968077

Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Hao Yang
, Xue Gou
, Kar Hang Chu
, Yong Wang
, Dong Sun

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

Abstract

Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.

Original language	English
Title of host publication	Proceedings of the IEEE Conference on Nanotechnology
Publisher	IEEE
Pages	742-746
Number of pages	5
ISBN (Electronic)	9781479956227
DOIs	https://doi.org/10.1109/NANO.2014.6968077
Publication status	Published - 26 Nov 2014
Externally published	Yes
Event	2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 - Toronto, Canada Duration: 18 Aug 2014 → 21 Aug 2014

Conference

Conference	2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
Country/Territory	Canada
City	Toronto
Period	18/08/14 → 21/08/14

ASJC Scopus subject areas

Electrical and Electronic Engineering
Computer Science Applications
Modelling and Simulation
Instrumentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1109/NANO.2014.6968077

Cite this

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title = "Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design",

abstract = "Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.",

author = "Hao Yang and Xue Gou and Chu, \{Kar Hang\} and Yong Wang and Dong Sun",

year = "2014",

month = nov,

day = "26",

doi = "10.1109/NANO.2014.6968077",

language = "English",

pages = "742--746",

booktitle = "Proceedings of the IEEE Conference on Nanotechnology",

publisher = "IEEE",

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note = "2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 ; Conference date: 18-08-2014 Through 21-08-2014",

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Yang, H, Gou, X, Chu, KH, Wang, Y & Sun, D 2014, Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design. in Proceedings of the IEEE Conference on Nanotechnology., 6968077, IEEE, pp. 742-746, 2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014, Toronto, Canada, 18/08/14. https://doi.org/10.1109/NANO.2014.6968077

Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design. / Yang, Hao; Gou, Xue; Chu, Kar Hang et al.
Proceedings of the IEEE Conference on Nanotechnology. IEEE, 2014. p. 742-746 6968077.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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AU - Gou, Xue

AU - Chu, Kar Hang

AU - Wang, Yong

AU - Sun, Dong

PY - 2014/11/26

Y1 - 2014/11/26

N2 - Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.

AB - Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.

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M3 - Conference article published in proceeding or book

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PB - IEEE

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Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Abstract

Conference

ASJC Scopus subject areas

UN SDGs

More information

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