Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Hao Yang, Xue Gou, Kar Hang Chu, Yong Wang, Dong Sun

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.
Original languageEnglish
Title of host publicationProceedings of the IEEE Conference on Nanotechnology
Number of pages5
ISBN (Electronic)9781479956227
Publication statusPublished - 26 Nov 2014
Externally publishedYes
Event2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 - Toronto, Canada
Duration: 18 Aug 201421 Aug 2014


Conference2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Modelling and Simulation
  • Instrumentation

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