Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Hao Yang, Xue Gou, Kar Hang Chu, Yong Wang, Dong Sun

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.
Original languageEnglish
Title of host publicationProceedings of the IEEE Conference on Nanotechnology
PublisherIEEE
Pages742-746
Number of pages5
ISBN (Electronic)9781479956227
DOIs
Publication statusPublished - 26 Nov 2014
Externally publishedYes
Event2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 - Toronto, Canada
Duration: 18 Aug 201421 Aug 2014

Conference

Conference2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
Country/TerritoryCanada
CityToronto
Period18/08/1421/08/14

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Modelling and Simulation
  • Instrumentation

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