Quality of life and pregnancy outcomes among women undergoing in vitro fertilization treatment: A longitudinal cohort study

Meng Hsing Wu, Pei Fang Su, Wei Ying Chu, New Geok Huey, Chih Wei Lin, Huang Tz Ou, Chung Ying Lin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)


Background/purpose: This study assessed the quality of life (QoL) and pregnancy outcomes among infertile women undergoing in vitro fertilization (IVF) treatment to investigate the association between QoL and IVF pregnancy outcomes. Methods: This study included 686 women with 1205 embryo transfers (ETs). QoL was measured using the fertility quality of life (FertiQoL) tool before ET. FertiQoL comprises two modules: a Core module (including mind/body, emotional, relational, and social domains) and a Treatment module (covering treatment environment and tolerability domains). The FertiQol total and subscale scores were computed and scored in the range of 0–100 (higher scores indicate better QoL). Multivariate generalized estimating equation analyses were carried out to assess the association between QoL and IVF pregnancy outcomes, with adjustment for time-varying factors across multiple ETs for a given person. Results: The lowest score in the core module was for the emotional domain (62.0), and that in the Treatment module was for the tolerability domain (59.4). QoL scores were significantly and positively associated with pregnancy outcomes (i.e., ongoing pregnancy, live birth); with a one unit increase in the emotional domain score, the probabilities of ongoing pregnancy and live birth significantly increased by 2.4% and 2.6%, respectively (p < 0.05). Conclusion: This study evaluated the prospective association between QoL and IVF pregnancy outcomes among infertile women. The results highlight the importance of developing clinical strategies to improve QoL among infertile women undergoing IVF treatment, which may further improve the pregnancy rates of this population.

Original languageEnglish
Pages (from-to)471-479
Number of pages9
JournalJournal of the Formosan Medical Association
Issue number1P3
Publication statusPublished - Jan 2020


  • FertiQoL
  • In vitro fertilization
  • Pregnancy
  • Quality of life

ASJC Scopus subject areas

  • Medicine(all)

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