Pulmonary kinematics from hyperpolarized helium-3 tagged magnetic resonance imaging

N. J. Tustison, T. A. Altes, J. C. Gee, Jing Cai, E. E. De Lange, J. P. Mugler

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)


Recent innovations in hyperpolarized Helium-3 magnetic resonance imaging (MRI) include the employment of MR tagging techniques for assessment of pulmonary deformation. Historically, such tagging methods have been successfully applied to cardiac research inspiring the development of computational techniques for the quantitative analysis of myocardial deformation. We present related research which concerns the calculation of kinematic quantities, such as displacement and strain, in the lung. Utilizing the high contrast tag lines as landmarks in the images and a recently developed fast n-D B-spline approximation algorithm, we fit a parametric object to the sparse tag line data to smoothly interpolate the underlying deformation field and, subsequently, extract lung kinematic information. We present results from a single human volunteer.
Original languageEnglish
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Number of pages4
Publication statusPublished - 27 Nov 2007
Externally publishedYes
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: 12 Apr 200715 Apr 2007


Conference2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
Country/TerritoryUnited States
CityArlington, VA


  • B-splines
  • Deformation analysis
  • Hyperpolarized Helium-3
  • Tagged MRI

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Medicine(all)

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