Proteomic investigations on the mechanism of neurotoxicity in low-dose chronic methylmercury intake

H. K. Kong, Chun Lap Samuel Lo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Contamination of seafood and especially fish with methylmercury is becoming a global issue. We fed rats with a low dose methylmercury (40 ug/kg body weight/day) for 3 months in order to see if the protein expressions in their brains were affected.With proteomic technologies, we found that the expression of about 100 proteins in the somatic sensory cortex was altered. A significant portion of these proteins are enzymes of the metabolic pathways. This finding is in line with the hypothesis that methylmercury accumulation in the brain caused decreased energy supply which eventually impaired ability for auto-repair in the brain.
Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalProgress in Nutrition
Volume13
Issue number3
Publication statusPublished - 1 Nov 2011

Keywords

  • Brain
  • Methylmercury
  • Proteomics

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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