Contamination of seafood and especially fish with methylmercury is becoming a global issue. We fed rats with a low dose methylmercury (40 ug/kg body weight/day) for 3 months in order to see if the protein expressions in their brains were affected.With proteomic technologies, we found that the expression of about 100 proteins in the somatic sensory cortex was altered. A significant portion of these proteins are enzymes of the metabolic pathways. This finding is in line with the hypothesis that methylmercury accumulation in the brain caused decreased energy supply which eventually impaired ability for auto-repair in the brain.
|Number of pages||3|
|Journal||Progress in Nutrition|
|Publication status||Published - 1 Nov 2011|
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics