Protective effects of huperzine A on β-amyloid25-35induced oxidative injury in rat pheochromocytoma cells

Xiao Qiu Xiao, Rui Wang, Yifan Han, Xi Can Tang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

77 Citations (Scopus)

Abstract

The effects of huperzine A (HupA), a novel acetylcholinesterase inhibitor, on Aβ25-35-induced cell lesion, level of lipid peroxidation, antioxidant enzyme activities were investigated in the rat pheochromocytoma line PC12. Following a 48 h exposure of the cells to Aβ25-35, a significant reduction in cell survival and activities of glutathione peroxidase (GSH-Px) and catalase (CAT), as well as increased production of malondialdehyde (MDA) and superoxide dismutase (SOD) were observed. Preincubation of the cells with HupA prior to Aβ25-35exposure elevated the cell survival and GSH-Px and CAT activities, and decreased the level of MDA and SOD activity. The results indicate that HupA has protective effects against Aβ-induced cell toxicity, which might be beneficial for the treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.
Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalNeuroscience Letters
Volume286
Issue number3
DOIs
Publication statusPublished - 9 Jun 2000
Externally publishedYes

Keywords

  • Amyloid β-peptide
  • Catalase
  • Free radicals
  • Glutathione peroxidase
  • Huperzine A
  • Malondialdehyde
  • PC12 cells
  • Superoxide dismutase

ASJC Scopus subject areas

  • Neuroscience(all)

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