Abstract
The effects of huperzine A (HupA), a novel acetylcholinesterase inhibitor, on Aβ25-35-induced cell lesion, level of lipid peroxidation, antioxidant enzyme activities were investigated in the rat pheochromocytoma line PC12. Following a 48 h exposure of the cells to Aβ25-35, a significant reduction in cell survival and activities of glutathione peroxidase (GSH-Px) and catalase (CAT), as well as increased production of malondialdehyde (MDA) and superoxide dismutase (SOD) were observed. Preincubation of the cells with HupA prior to Aβ25-35exposure elevated the cell survival and GSH-Px and CAT activities, and decreased the level of MDA and SOD activity. The results indicate that HupA has protective effects against Aβ-induced cell toxicity, which might be beneficial for the treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 155-158 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 286 |
Issue number | 3 |
DOIs | |
Publication status | Published - 9 Jun 2000 |
Externally published | Yes |
Keywords
- Amyloid β-peptide
- Catalase
- Free radicals
- Glutathione peroxidase
- Huperzine A
- Malondialdehyde
- PC12 cells
- Superoxide dismutase
ASJC Scopus subject areas
- General Neuroscience