TY - JOUR
T1 - Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress
AU - Wang, Jun
AU - Zhao, Danyue
AU - Tiano, Simoni
AU - Esteban-Fernández, Adelaida
AU - Yuan, Bo
AU - Smith, Chad
AU - Brathwaite, Justin
AU - Jlayer, Zahra
AU - Wu, Qingli
AU - Simon, James E.
AU - Trageser, Kyle J.
AU - Pasinetti, Giulio M.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.
AB - Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.
UR - https://www.scopus.com/pages/publications/85086165317
U2 - 10.1038/s41398-020-0859-x
DO - 10.1038/s41398-020-0859-x
M3 - Journal article
C2 - 32518327
AN - SCOPUS:85086165317
SN - 2158-3188
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 183
ER -
