@article{054eb16148184c12a56fef9cbf7dbfbf,
title = "Property-tuneable microgels fabricated by using flow-focusing microfluidic geometry for bioactive agent delivery",
abstract = "Gelatine methacryloyl (GM) shows high biocompatibility and is extensively used in tissue engineering; however, few works have explored the use of GM in bioactive agent delivery. This study adopts a microfluidic approach involving the use of flow-focusing microfluidic geometry for microgel fabrication. This approach generates highly monodisperse microgels whose size can be tuned by altering various fabrication conditions (including the concentration of the gel-forming solution and the flow rates of different phases). By using tetracycline hydrochloride as a model agent, the fabricated microgels enable prolonged agent release, with the encapsulation efficiency being around 30–40% depending on the concentration of the gel-forming solution. Along with their negligible cytotoxicity, our microgels show the potential to serve as carriers of bioactive agents for food and pharmaceutical applications.",
keywords = "Controlled release, Flow-focusing geometry, Microfluidics, Microgels, Nutraceuticals",
author = "Lai, {Wing Fu} and Wong, {Wing Tak}",
note = "Funding Information: This research was funded by the Chinese University of Hong Kong, Shenzhen UDF01001421 and UF02001421) and the Research Grants Council of the Government of Hong Kong (PF01001421, UDF01001421 and UF02001421) and the Research Grants Council of the Government Special of Hong Administrative Kong Special Administrative Region (C5012-15E). Region (C5012-15E). Funding Information: Author Contributions: Conceptualization, W.-F.L. and W.-T.W.; formal analysis, W.-F.L.; supervi-W.-F.L.; project administration, W.-F.L.; funding acquisition, W.-F.L. and W.-T.W. Both authors have sion, W.-F.L.; project administration, W.-F.L.; funding acquisition, W.-F.L. and W.-T.W. All authors read and agreed to the published version of the manuscript. have read and agreed to the published version of the manuscript. Funding: This research was funded by the Chinese University of Hong Kong, Shenzhen (PF01001421, Funding: This research was funded by the Chinese University of Hong Kong, Shenzhen UDF01001421 and UF02001421) and the Research Grants Council of the Government of Hong Kong (PF01001421, UDF01001421 and UF02001421) and the Research Grants Council of the Government Specialof Hong Kong AdministrativeSpecial AdministrativeRegion (C5012-15E).Region (C5012-15E). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jun,
doi = "10.3390/pharmaceutics13060787",
language = "English",
volume = "13",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}