TY - JOUR
T1 - Prognostic variables in patients with diffuse large-cell lymphoma treated with MACOP-B
AU - Hoskins, P. J.
AU - Ng, Vincent To Yee
AU - Spinelli, J. J.
AU - Klimo, P.
AU - Connors, J. M.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - One hundred twenty-six patients with diffuse large-cell lymphoma were treated with methotrexate with leucovorin, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B) between April 1981 and June 1986. Univariate and multivariate analyses were performed using overall survival as of September 1989 as the end point. Four independent negative predictors of survival were identified: presence of B symptoms; more than two involved lymph node sites; more than one extranodal site (variables related to tumor burden), and age older than 60, a variable related to the patient's ability to tolerate treatment. Each variable contributed the same relative risk of dying and, accordingly, this simple predictive formula was developed empirically: (4 - N) x 30 = the approximate percentage of chance of survival at 5 years. 'N' is the number of predictive variables present. The same four predictors were also found to be significant by multivariate analysis when only those patients achieving a complete response were analyzed.
AB - One hundred twenty-six patients with diffuse large-cell lymphoma were treated with methotrexate with leucovorin, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B) between April 1981 and June 1986. Univariate and multivariate analyses were performed using overall survival as of September 1989 as the end point. Four independent negative predictors of survival were identified: presence of B symptoms; more than two involved lymph node sites; more than one extranodal site (variables related to tumor burden), and age older than 60, a variable related to the patient's ability to tolerate treatment. Each variable contributed the same relative risk of dying and, accordingly, this simple predictive formula was developed empirically: (4 - N) x 30 = the approximate percentage of chance of survival at 5 years. 'N' is the number of predictive variables present. The same four predictors were also found to be significant by multivariate analysis when only those patients achieving a complete response were analyzed.
UR - http://www.scopus.com/inward/record.url?scp=0026029124&partnerID=8YFLogxK
U2 - 10.1200/JCO.1991.9.2.220
DO - 10.1200/JCO.1991.9.2.220
M3 - Journal article
C2 - 1703227
VL - 9
SP - 220
EP - 226
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 2
ER -