Prognostic variables in patients with diffuse large-cell lymphoma treated with MACOP-B

P. J. Hoskins, Vincent To Yee Ng, J. J. Spinelli, P. Klimo, J. M. Connors

Research output: Journal article publicationJournal articleAcademic researchpeer-review

73 Citations (Scopus)


One hundred twenty-six patients with diffuse large-cell lymphoma were treated with methotrexate with leucovorin, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B) between April 1981 and June 1986. Univariate and multivariate analyses were performed using overall survival as of September 1989 as the end point. Four independent negative predictors of survival were identified: presence of B symptoms; more than two involved lymph node sites; more than one extranodal site (variables related to tumor burden), and age older than 60, a variable related to the patient's ability to tolerate treatment. Each variable contributed the same relative risk of dying and, accordingly, this simple predictive formula was developed empirically: (4 - N) x 30 = the approximate percentage of chance of survival at 5 years. 'N' is the number of predictive variables present. The same four predictors were also found to be significant by multivariate analysis when only those patients achieving a complete response were analyzed.
Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalJournal of Clinical Oncology
Issue number2
Publication statusPublished - 1 Jan 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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