TY - JOUR
T1 - Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging
AU - Sorond, Farzaneh A.
AU - Whitehead, Shawn
AU - Arai, Ken
AU - Arnold, Douglas
AU - Carmichael, S. Thomas
AU - De Carli, Charles
AU - Duering, Marco
AU - Fornage, Myriam
AU - Flores-Obando, Rafael E.
AU - Graff-Radford, Jonathan
AU - Hamel, Edith
AU - Hess, David C.
AU - Ihara, Massafumi
AU - Jensen, Majken K.
AU - Markus, Hugh S.
AU - Montagne, Axel
AU - Rosenberg, Gary
AU - Shih, Andy Y.
AU - Smith, Eric E.
AU - Thiel, Alex
AU - Tse, Kai Hei
AU - Wilcock, Donna
AU - Barone, Frank
PY - 2020/2
Y1 - 2020/2
N2 - This third in a series of vascular cognitive impairment (VCI) workshops, supported by “The Leo and Anne Albert Charitable Trust,” was held from February 8 to 12 at the Omni Resort in Carlsbad, CA. This workshop followed the information gathered from the earlier two workshops suggesting that we focus more specifically on brain white matter in age-related cognitive impairment. The Scientific Program Committee (Frank Barone, Shawn Whitehead, Eric Smith, and Rod Corriveau) assembled translational, clinical, and basic scientists with unique expertise in acute and chronic white matter injury at the intersection of cerebrovascular and neurodegenerative etiologies. As in previous Albert Trust workshops, invited participants addressed key topics related to mechanisms of white matter injury, biomarkers of white matter injury, and interventions to prevent white matter injury and age-related cognitive decline. This report provides a synopsis of the presentations and discussions by the participants, including the existing knowledge gaps and the delineation of the next steps towards advancing our understanding of white matter injury and age-related cognitive decline. Workshop discussions and consensus resulted in action by The Albert Trust to (1) increase support from biannual to annual “White Matter and Cognition” workshops; (2) provide funding for two collaborative, novel research grants annually submitted by meeting participants; and (3) coordinate the formation of the “Albert Research Institute for White Matter and Cognition.” This institute will fill a gap in white matter science, providing white matter and cognition communications, including annual updates from workshops and the literature and interconnecting with other Albert Trust scientific endeavors in cognition and dementia, and providing support for newly established collaborations between seasoned investigators and to the development of talented young investigators in the VCI-dementia (VCID) and white matter cognition arena.
AB - This third in a series of vascular cognitive impairment (VCI) workshops, supported by “The Leo and Anne Albert Charitable Trust,” was held from February 8 to 12 at the Omni Resort in Carlsbad, CA. This workshop followed the information gathered from the earlier two workshops suggesting that we focus more specifically on brain white matter in age-related cognitive impairment. The Scientific Program Committee (Frank Barone, Shawn Whitehead, Eric Smith, and Rod Corriveau) assembled translational, clinical, and basic scientists with unique expertise in acute and chronic white matter injury at the intersection of cerebrovascular and neurodegenerative etiologies. As in previous Albert Trust workshops, invited participants addressed key topics related to mechanisms of white matter injury, biomarkers of white matter injury, and interventions to prevent white matter injury and age-related cognitive decline. This report provides a synopsis of the presentations and discussions by the participants, including the existing knowledge gaps and the delineation of the next steps towards advancing our understanding of white matter injury and age-related cognitive decline. Workshop discussions and consensus resulted in action by The Albert Trust to (1) increase support from biannual to annual “White Matter and Cognition” workshops; (2) provide funding for two collaborative, novel research grants annually submitted by meeting participants; and (3) coordinate the formation of the “Albert Research Institute for White Matter and Cognition.” This institute will fill a gap in white matter science, providing white matter and cognition communications, including annual updates from workshops and the literature and interconnecting with other Albert Trust scientific endeavors in cognition and dementia, and providing support for newly established collaborations between seasoned investigators and to the development of talented young investigators in the VCI-dementia (VCID) and white matter cognition arena.
KW - Aging
KW - Blood-brain barrier
KW - Brain white matter
KW - Cognition
KW - Myelin
KW - Neurovascular
KW - Oligovascular
KW - Vascular cognitive impairment (VCID)
UR - http://www.scopus.com/inward/record.url?scp=85076224917&partnerID=8YFLogxK
U2 - 10.1007/s11357-019-00141-8
DO - 10.1007/s11357-019-00141-8
M3 - Review article
C2 - 31811528
AN - SCOPUS:85076224917
SN - 2509-2715
VL - 42
SP - 81
EP - 96
JO - GeroScience
JF - GeroScience
IS - 1
ER -