Prevalence of depression and its association with quality of life in clinically stable patients with COVID-19

Yu Fen Ma, Wen Li, Hai Bao Deng, Lei Wang, Ying Wang, Pei Hong Wang, Hai Xin Bo, Jing Cao, Yu Wang, Li Yun Zhu, Yuan Yang, Teris Cheung, Chee H. Ng, Xinjuan Wu, Yu Tao Xiang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

58 Citations (Scopus)


Introduction: High risk of mental health problems is associated with Coronavirus Disease 2019 (COVID-19). This study explored the prevalence of depressive symptoms (depression hereafter) and its relationship with quality of life (QOL) in clinically stable patients with COVID-19. Methods: This was an online survey conducted in COVID-19 patients across five designated isolation hospitals for COVID-19 in Hubei province, China. Depression and QOL were assessed with standardized instruments. Results: A total of 770 participants were included. The prevalence of depression was 43.1% (95%CI: 39.6%-46.6%). Binary logistic regression analysis found that having a family member infected with COVID-19 (OR=1.51, P = 0.01), suffering from severe COVID-19 infection (OR=1.67, P = 0.03), male gender (OR=0.53, P<0.01), and frequent social media use to obtain COVID-19 related information (OR=0.65, P<0.01) were independently associated with depression. Patients with depression had lower QOL than those without. Conclusion: Depression is highly prevalent in clinically stable patients with COVID-19. Regular screening and appropriate treatment of depression are urgently warranted for this population.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Affective Disorders
Publication statusPublished - 1 Oct 2020


  • COVID-19
  • Depression
  • Quality of life
  • Stable

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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