Preparation of quantum dot/drug nanoparticle formulations for traceable targeted delivery and therapy

Ken Tye Yong, Yucheng Wang, Indrajit Roy, Hu Rui, Mark T. Swihart, Wing Cheung Law, Sang Kyu Kwak, Ling Ye, Jianwei Liu, Supriya D. Mahajan, Jessica L. Reynolds

Research output: Journal article publicationJournal articleAcademic researchpeer-review

72 Citations (Scopus)

Abstract

Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recent advancement in making biocompatible QD formulations has made these nanocrystals suitable for in vivo applications. This review provides an overview of the preparation of QDs and their use as probes or carriers for traceable, targeted therapy of diseases in vitro and in vivo. More specifically, recent advances in the integration of QDs with drug formulations for therapy and their potential toxicity in vitro and in vivo are highlighted. The current findings and challenges for optimizing QD/drug formulations with respect to optimal size and stability, short-term and longterm toxicity, and in vivo applications are described. Lastly, we attempt to predict key trends in QD/drug formulation development over the next few years and highlight areas of therapy where their use may provide breakthrough results in the near future.
Original languageEnglish
Pages (from-to)681-694
Number of pages14
JournalTheranostics
Volume2
Issue number7
DOIs
Publication statusPublished - 14 Sep 2012
Externally publishedYes

Keywords

  • Drug nanoparticle formulations
  • Quantum dots
  • Targeted delivery

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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