Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Kim Hung Lam, Roberto Gambari, Kenneth Ka Ho Lee, Yi Xin Chen, Stanton Hon Lung Kok, Raymond Siu Ming Wong, Fung Yi Lau, Chor Hing Cheng, Wai Yeung Wong, Zhao Xiang Bian, Albert Sun Chi Chan, Cheuk On Tang, Chung Hin Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

33 Citations (Scopus)

Abstract

This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.
Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Antibacterial agents
  • Antibiotics
  • Quinolines
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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