Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Kim Hung Lam; Roberto Gambari; Kenneth Ka Ho Lee; Yi Xin Chen; Stanton Hon Lung Kok; Raymond Siu Ming Wong; Fung Yi Lau; Chor Hing Cheng; Wai Yeung Wong; Zhao Xiang Bian; Albert Sun Chi Chan; Cheuk On Tang; Chung Hin Chui

doi:10.1016/j.bmcl.2013.10.072

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Kim Hung Lam, Roberto Gambari, Kenneth Ka Ho Lee, Yi Xin Chen, Stanton Hon Lung Kok, Raymond Siu Ming Wong, Fung Yi Lau, Chor Hing Cheng, Wai Yeung Wong, Zhao Xiang Bian, Albert Sun Chi Chan, Cheuk On Tang, Chung Hin Chui

Research output: Journal article publication › Journal article › Academic research › peer-review

45 Citations (Scopus)

Abstract

This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.

Original language	English
Pages (from-to)	367-370
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2013.10.072
Publication status	Published - 1 Jan 2014

Keywords

Antibacterial agents
Antibiotics
Quinolines
Staphylococcus aureus

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.10.072

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Lam, K. H., Gambari, R., Lee, K. K. H., Chen, Y. X., Kok, S. H. L., Wong, R. S. M., Lau, F. Y., Cheng, C. H., Wong, W. Y., Bian, Z. X., Chan, A. S. C., Tang, C. O., & Chui, C. H. (2014). Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus. Bioorganic and Medicinal Chemistry Letters, 24(1), 367-370. https://doi.org/10.1016/j.bmcl.2013.10.072

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abstract = "This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.",

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AU - Gambari, Roberto

AU - Lee, Kenneth Ka Ho

AU - Chen, Yi Xin

AU - Kok, Stanton Hon Lung

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Cheng, Chor Hing

AU - Wong, Wai Yeung

AU - Bian, Zhao Xiang

AU - Chan, Albert Sun Chi

AU - Tang, Cheuk On

AU - Chui, Chung Hin

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KW - Antibacterial agents

KW - Antibiotics

KW - Quinolines

KW - Staphylococcus aureus

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DO - 10.1016/j.bmcl.2013.10.072

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Abstract

Keywords

ASJC Scopus subject areas

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