Preparation of 2-(2-(dicyclohexylphosphino)phenyl)-1-methyl-1h-indole (CM-phos)

Shun Man Wong, On Ying Yuen, Pui Ying Choy, Chau Ming So, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

The article describes the preparation of 2-(2-(Dicyclohexylphosphino) phenyl)-1-methyl-1H-indole (CM-phos).We selected the Fischer indole synthesis as our primary tool to synthesize the indole templates from phenylhydrazine and 2’-bromoacetophenone. With the methylated ligand precursor, CM-phos could be afforded easily by lithiation and subsequently trapping with chlorodicyclohexylphosphine. It should be noted that CM-phos in combination with the precatalyst palladium(II) acetate is highly active and effective in amination and Suzuki cross-coupling reaction of aryl mesylates.

Original languageEnglish
JournalOrganic Syntheses
Volume93
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Chemical-specific hazards
  • CM-phos
  • Fischer indole synthesis
  • Ligand design
  • Metal-catalyzed coupling reactions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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