Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan

Patrick Chi Leung Hui; Wen Yi Wang; Chi Wai Kan; Chang E. Zhou; Frency Sau Fun Ng; Elaine Wat; Vanilla Xin Zhang; Chung Lap Chan; Clara Bik San Lau; Ping Chung Leung

doi:10.1016/j.ijbiomac.2012.12.023

Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan

Patrick Chi Leung Hui, Wen Yi Wang, Chi Wai Kan, Chang E. Zhou, Frency Sau Fun Ng, Elaine Wat, Vanilla Xin Zhang, Chung Lap Chan, Clara Bik San Lau, Ping Chung Leung

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

21 Citations (Scopus)

Abstract

The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio = 1:2; (ii) chitosan concentration = 6% (w/v); (iii) agitation speed = 1100. rpm; and (iv) cross-linking time = 90. min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48. h and the release rate became steady after that.

Original language	English
Pages (from-to)	32-38
Number of pages	7
Journal	International Journal of Biological Macromolecules
Volume	55
DOIs	https://doi.org/10.1016/j.ijbiomac.2012.12.023
Publication status	Published - Apr 2013

Keywords

Atopic dermatitis
Controlled-release
Cortex Moutan
Microencapsulation
Orthogonal array analysis

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Biology
Economics and Econometrics
General Energy

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10.1016/j.ijbiomac.2012.12.023

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title = "Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan",

abstract = "The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio = 1:2; (ii) chitosan concentration = 6% (w/v); (iii) agitation speed = 1100. rpm; and (iv) cross-linking time = 90. min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48. h and the release rate became steady after that.",

keywords = "Atopic dermatitis, Controlled-release, Cortex Moutan, Microencapsulation, Orthogonal array analysis",

author = "Hui, {Patrick Chi Leung} and Wang, {Wen Yi} and Kan, {Chi Wai} and Zhou, {Chang E.} and Ng, {Frency Sau Fun} and Elaine Wat and Zhang, {Vanilla Xin} and Chan, {Chung Lap} and Lau, {Clara Bik San} and Leung, {Ping Chung}",

note = "Funding Information: We gratefully acknowledge financial support from Innovation and Technology Fund of the Government of the Hong Kong Special Administrative Region (Project Code: ITS/409/09) and the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. PolyU 5171/10E).",

year = "2013",

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doi = "10.1016/j.ijbiomac.2012.12.023",

language = "English",

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pages = "32--38",

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AU - Hui, Patrick Chi Leung

AU - Wang, Wen Yi

AU - Kan, Chi Wai

AU - Zhou, Chang E.

AU - Ng, Frency Sau Fun

AU - Wat, Elaine

AU - Zhang, Vanilla Xin

AU - Chan, Chung Lap

AU - Lau, Clara Bik San

AU - Leung, Ping Chung

N1 - Funding Information: We gratefully acknowledge financial support from Innovation and Technology Fund of the Government of the Hong Kong Special Administrative Region (Project Code: ITS/409/09) and the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. PolyU 5171/10E).

PY - 2013/4

Y1 - 2013/4

N2 - The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio = 1:2; (ii) chitosan concentration = 6% (w/v); (iii) agitation speed = 1100. rpm; and (iv) cross-linking time = 90. min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48. h and the release rate became steady after that.

AB - The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio = 1:2; (ii) chitosan concentration = 6% (w/v); (iii) agitation speed = 1100. rpm; and (iv) cross-linking time = 90. min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48. h and the release rate became steady after that.

KW - Atopic dermatitis

KW - Controlled-release

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KW - Microencapsulation

KW - Orthogonal array analysis

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Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan

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Keywords

ASJC Scopus subject areas

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