Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan

Chi Leung Hui, Wen Yi Wang, Chi Wai Kan, Chang E. Zhou, Frency Sau Fun Ng, Elaine Wat, Vanilla Xin Zhang, Chung Lap Chan, Clara Bik San Lau, Ping Chung Leung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)

Abstract

The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio = 1:2; (ii) chitosan concentration = 6% (w/v); (iii) agitation speed = 1100. rpm; and (iv) cross-linking time = 90. min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48. h and the release rate became steady after that.
Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume55
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • Atopic dermatitis
  • Controlled-release
  • Cortex Moutan
  • Microencapsulation
  • Orthogonal array analysis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Cite this